Drug Information

Drug General Information
Drug ID
D0P1YE
Former ID
DCL000585
Drug Name
Orvepitant
Drug Type
Small molecular drug
Indication Depression; Anxiety [ICD9: 300, 311; ICD10:F30-F39, F40-F42] Phase 2 [547887]
Company
GSK
Structure
Download
2D MOL

3D MOL
Formula
C31H35F7N4O2
Canonical SMILES
CC1=C(C=CC(=C1)F)C2CC(CCN2C(=O)N(C)C(C)C3=CC(=CC(=C3)C(<br />F)(F)F)C(F)(F)F)N4CCN5C(C4)CCC5=O
InChI
1S/C31H35F7N4O2/c1-18-12-23(32)4-6-26(18)27-16-24(40-10-11-41-25(17-40)5-7-28(41)43)8-9-42(27)29(44)39(3)19(2)20-13-21(30(33,34)35)15-22(14-20)31(36,37)38/h4,6,12-15,19,24-25,27H,5,7-11,16-17H2,1-3H3/t19-,24+,25+,27-/m1/s1
InChIKey
XWNBGDJPEXZSQM-VZOBGQTKSA-N
PubChem Compound ID
9852175
PubChem Substance ID
15217862, 24147654, 45274498, 76861848, 124490390, 134339142, 135261421, 138589914, 160703513, 175454902, 198941755, 223959973, 227634351, 245612485
Target and Pathway
Target(s) Substance-P receptor Target Info Antagonist [550963]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Measles
PANTHER Pathway CCKR signaling map ST
Reactome G alpha (q) signalling events
WikiPathways SIDS Susceptibility Pathways
Gastrin-CREB signalling pathway via PKC and MAPK
Spinal Cord Injury
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 547887Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800020168)
Ref 550963Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).

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