Drug Information

Drug General Information
Drug ID
D0P1WB
Former ID
DIB004341
Drug Name
EVT-301
Synonyms
MAO B inhibitors (Alzheimer's disease), Evotec/Roche; Monoamineoxidase B inhibitors (Alzheimer's disease),Evotec/Roche
Indication Alzheimer disease [ICD9: 331; ICD10:G30] Discontinued in Phase 1 [548293]
Company
Roche Holding AG
Target and Pathway
Target(s) Amine oxidase [flavin-containing] B Target Info Inhibitor [529908]
BioCyc Pathway Superpathway of tryptophan utilization
Tryptophan degradation via tryptamine
Dopamine degradation
Putrescine degradation III
Noradrenaline and adrenaline degradation
KEGG Pathway Glycine, serine and threonine metabolism
Arginine and proline metabolism
Histidine metabolism
Tyrosine metabolism
Phenylalanine metabolism
Tryptophan metabolism
Drug metabolism - cytochrome P450
Metabolic pathways
Serotonergic synapse
Dopaminergic synapse
Cocaine addiction
Amphetamine addiction
Alcoholism
PANTHER Pathway Adrenaline and noradrenaline biosynthesis
5-Hydroxytryptamine degredation
Dopamine receptor mediated signaling pathway
Pathway Interaction Database Alpha-synuclein signaling
WikiPathways Tryptophan metabolism
Dopamine metabolism
Phase 1 - Functionalization of compounds
References
Ref 548293Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800024230)
Ref 529908Assessment of MAO-B occupancy in the brain with PET and [11C]-L-deprenyl-D2: a dose-finding study with a novel MAO-B inhibitor, EVT 301. Clin Pharmacol Ther. 2009 May;85(5):506-12.

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