| Drug General Information |
| Drug ID |
D0P1HI
|
| Former ID |
DIB001060
|
| Drug Name |
ROCK-1 inhibitors
|
| Synonyms |
ROCK-1 inhibitors (atherosclerosis); ROCK-1 inhibitors (atherosclerosis), MSD; ROCK-1 inhibitors (atherosclerosis), Merck
|
| Indication |
Atherosclerosis [ICD9: 414.0, 440; ICD10:I70]
|
Investigative |
[1]
|
|---|
| Company |
Merck & Co Inc
|
| Structure |
|
Download
2D MOL
3D MOL
|
| Canonical SMILES |
c1(ccc2c(c1)cc[nH]c2=O)O[C@H]1CCCNC1
|
| Target and Pathway |
| Target(s) |
Rho-associated protein kinase 1 |
Target Info |
Inhibitor |
[2]
|
|---|
|
KEGG Pathway
|
cGMP-PKG signaling pathway
|
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cAMP signaling pathway
|
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Chemokine signaling pathway
|
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Sphingolipid signaling pathway
|
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Vascular smooth muscle contraction
|
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TGF-beta signaling pathway
|
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Axon guidance
|
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Focal adhesion
|
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Platelet activation
|
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Leukocyte transendothelial migration
|
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Regulation of actin cytoskeleton
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Oxytocin signaling pathway
|
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Pathogenic Escherichia coli infection
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Shigellosis
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Salmonella infection
|
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Pathways in cancer
|
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Proteoglycans in cancer
|
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MicroRNAs in cancer
|
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PANTHER Pathway
|
Cytoskeletal regulation by Rho GTPase
|
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Inflammation mediated by chemokine and cytokine signaling pathway
|
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CCKR signaling map ST
|
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Pathway Interaction Database
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Signaling events mediated by PRL
|
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RhoA signaling pathway
|
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Noncanonical Wnt signaling pathway
|
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EPHB forward signaling
|
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Thromboxane A2 receptor signaling
|
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PAR4-mediated thrombin signaling events
|
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amb2 Integrin signaling
|
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Integrins in angiogenesis
|
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EPHA forward signaling
|
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Stabilization and expansion of the E-cadherin adherens junction
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Signaling events mediated by VEGFR1 and VEGFR2
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PAR1-mediated thrombin signaling events
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N-cadherin signaling events
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Reactome
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Apoptotic cleavage of cellular proteins
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EPHB-mediated forward signaling
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EPHA-mediated growth cone collapse
|
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G alpha (12/13) signalling events
|
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Sema4D induced cell migration and growth-cone collapse
|
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VEGFA-VEGFR2 Pathway
|
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RHO GTPases Activate ROCKs
|
|
WikiPathways
|
G13 Signaling Pathway
|
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Regulation of Actin Cytoskeleton
|
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EGF/EGFR Signaling Pathway
|
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TGF beta Signaling Pathway
|
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Focal Adhesion
|
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JAK/STAT
|
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AGE/RAGE pathway
|
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Pathogenic Escherichia coli infection
|
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Regulation of Microtubule Cytoskeleton
|
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Leptin signaling pathway
|
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Semaphorin interactions
|
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Integrin-mediated Cell Adhesion
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GPCR downstream signaling
|
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Apoptotic execution phase
|
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MicroRNAs in cardiomyocyte hypertrophy
|
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Androgen receptor signaling pathway
|
| References |
| REF 1 | ROCK1 is a potential combinatorial drug target for BRAF mutant melanoma. Mol Syst Biol. 2014 Dec 23;10:772 |
|---|
| REF 2 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1503). |
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