Drug General Information
Drug ID	D0P0QI
Former ID	DIB021180
Drug Name	VU0285683
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[541535]
Structure		Download 2D MOL
Formula	C14H7FN4O
InChI	InChI=1S/C14H7FN4O/c15-11-6-9(8-16)5-10(7-11)14-18-13(19-20-14)12-3-1-2-4-17-12/h1-7H
InChIKey	GELAFISMURFRCA-UHFFFAOYSA-N
PubChem Compound ID	9816778
PubChem Substance ID	14774818, 24121222, 44852745, 78019564, 140375273, 163313807, 163344967, 178103014, 196377570, 223800282, 230148984, 241376963, 248760228, 249691193, 252158012
Target and Pathway
Target(s)	Metabotropic glutamate receptor 5	Target Info	Modulator (allosteric modulator)	[531194]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Gap junction
	Long-term potentiation
	Retrograde endocannabinoid signaling
	Glutamatergic synapse
	Huntington's disease
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Metabotropic glutamate receptor group III pathway
	Metabotropic glutamate receptor group I pathway
	Endogenous cannabinoid signaling
Reactome	G alpha (q) signalling events
	Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways	Hypothetical Network for Drug Addiction
	GPCRs, Class C Metabotropic glutamate, pheromone
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 541535	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6398).
Ref 531194	Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity. Mol Pharmacol. 2010 Dec;78(6):1105-23.

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