Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0OU7P
|
||||
| Former ID |
DNC001339
|
||||
| Drug Name |
SKF 38393
|
||||
| Drug Type |
Small molecular drug
|
||||
| Indication | Type 2 diabetes [ICD9: 250; ICD10:E11] | Terminated | [1], [2] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C16H17NO2
|
||||
| InChI |
InChI=1S/C16H17NO2/c18-15-8-12-6-7-17-10-14(13(12)9-16(15)19)11-4-2-1-3-5-11/h1-5,8-9,14,17-19H,6-7,10H2
|
||||
| InChIKey |
JUDKOGFHZYMDMF-UHFFFAOYSA-N
|
||||
| CAS Number |
CAS 159795-65-0
|
||||
| PubChem Compound ID | |||||
| PubChem Substance ID |
6607884, 7980603, 8151056, 12013073, 14847852, 24439587, 26612740, 26747137, 26751970, 47365415, 47810976, 47810977, 47959975, 48035350, 48259459, 49877950, 50104645, 53787894, 57320837, 77323032, 85209305, 85788760, 90340892, 103102085, 103209798, 103918470, 104297170, 117616123, 124749714, 124879803, 124879804, 124879805, 126407030, 128328006, 134338871, 134340537, 135008800, 135651048, 137010202, 140305604, 162223778, 162884055, 179231005, 179578147, 226787234
|
||||
| Target and Pathway | |||||
| Target(s) | Dopamine D1 receptor | Target Info | Modulator | [1] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| cAMP signaling pathway | |||||
| Neuroactive ligand-receptor interaction | |||||
| Gap junction | |||||
| Dopaminergic synapse | |||||
| Parkinson's disease | |||||
| Cocaine addiction | |||||
| Amphetamine addiction | |||||
| Morphine addiction | |||||
| Alcoholism | |||||
| PANTHER Pathway | Dopamine receptor mediated signaling pathway | ||||
| PathWhiz Pathway | Dopamine Activation of Neurological Reward System | ||||
| Reactome | Dopamine receptors | ||||
| G alpha (s) signalling events | |||||
| WikiPathways | Hypothetical Network for Drug Addiction | ||||
| Monoamine GPCRs | |||||
| GPCRs, Class A Rhodopsin-like | |||||
| Genes and (Common) Pathways Underlying Drug Addiction | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | The D1 dopamine receptor agonist SKF-38393 stimulates the release of glutamate in the hippocampus. Neuroscience. 1999;94(4):1063-70. | ||||
| REF 2 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 935). | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.