Drug General Information
Drug ID	D0OC6H
Former ID	DIB011692
Drug Name	S-024
Synonyms	Chk1 inhibitors (cancer); S-024; S-144; Chk1 inhibitors (cancer), Sentinel
Indication	Cancer [ICD9: 140-229; ICD10:C00-C96]		Investigative	[543531]
Company	Sentinel Oncology Ltd
Structure		Download 2D MOL 3D MOL
Canonical SMILES	C[N+](C)(CCCOc1c(NC(=O)Nc2cnc(cn2)C#N)cc(cc1)Cl)[O-]
Target and Pathway
Target(s)	Serine/threonine-protein kinase Chk1	Target Info	Inhibitor	[543531]
KEGG Pathway	Cell cycle
	p53 signaling pathway
	HTLV-I infection
	Viral carcinogenesis
Pathway Interaction Database	Fanconi anemia pathway
	p73 transcription factor network
	ATR signaling pathway
	Circadian rhythm pathway
	p53 pathway
Reactome	Activation of ATR in response to replication stress
	Processing of DNA double-strand break ends
	Presynaptic phase of homologous DNA pairing and strand exchange
	G2/M DNA damage checkpoint
	Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
	Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
WikiPathways	DNA Damage Response
	Signaling by SCF-KIT
	ATM Signaling Pathway
	Retinoblastoma (RB) in Cancer
	Integrated Pancreatic Cancer Pathway
	Prostate Cancer
	Integrated Breast Cancer Pathway
	Integrated Cancer pathway
	Cell Cycle
	Cell Cycle Checkpoints
	miRNA Regulation of DNA Damage Response
References
Ref 543531	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1987).
Ref 543531	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1987).

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