Drug General Information
Drug ID	D0O7NV
Former ID	DIB013171
Drug Name	DOV-51892
Synonyms	DOV-22047; GABA-A modulators, DOV
Indication	Panic disorder [ICD9: 300.01, 300.21; ICD10:F41.0]		Investigative	[543814]
Company	DOV Pharmaceutical Inc
Structure		Download 2D MOL 3D MOL
Canonical SMILES	C(=O)(c1c2nccc(n2nc1)c1cc(ncc1)Cl)c1ccccn1
Target and Pathway
Target(s)	GABA A receptor	Target Info	Modulator	[543814]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Retrograde endocannabinoid signaling
	GABAergic synapse
	Morphine addiction
	Nicotine addiction
Reactome	Ligand-gated ion channel transport
	GABA A receptor activation
WikiPathways	SIDS Susceptibility Pathways
	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	Iron uptake and transport
References
Ref 543814	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 415).
Ref 543814	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 415).

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