Drug Information

Drug General Information
Drug ID
D0O3XZ
Former ID
DIB018539
Drug Name
2-amino-4-methylpyridine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [468175]
Structure
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2D MOL

3D MOL
Formula
C6H8N2
InChI
InChI=1S/C6H8N2/c1-5-2-3-8-6(7)4-5/h2-4H,1H3,(H2,7,8)
InChIKey
ORLGLBZRQYOWNA-UHFFFAOYSA-N
PubChem Compound ID
1533
PubChem Substance ID
68291, 72921, 804786, 3135554, 4360703, 8001646, 8151170, 10533060, 11110162, 11113859, 15297036, 16957255, 17137096, 24439861, 24847520, 29202831, 30400528, 48334608, 49829742, 50010602, 53776794, 55161693, 57320933, 58021839, 78981627, 85090604, 85787229, 87562037, 87623816, 92710798, 99215312, 103218645, 103990026, 104297993, 104667508, 117410137, 117651848, 118050396, 118080816, 121282124, 125002173, 125356288, 126522449, 126555554, 126581492, 126588349, 126631507, 126657934, 126669218, 126734719
Target and Pathway
Target(s) Nitric oxide synthase, inducible Target Info Inhibitor [534283]
BioCyc Pathway Citrulline-nitric oxide cycle
KEGG Pathway Arginine biosynthesis
Arginine and proline metabolism
Metabolic pathways
Calcium signaling pathway
HIF-1 signaling pathway
Peroxisome
Salmonella infection
Pertussis
Leishmaniasis
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Amoebiasis
Tuberculosis
Pathways in cancer
Small cell lung cancer
NetPath Pathway IL1 Signaling Pathway
IL2 Signaling Pathway
Pathway Interaction Database IL12-mediated signaling events
Alpha9 beta1 integrin signaling events
ATF-2 transcription factor network
IL23-mediated signaling events
Signaling mediated by p38-alpha and p38-beta
HIF-1-alpha transcription factor network
Reactome ROS production in response to bacteria
Nitric oxide stimulates guanylate cyclase
WikiPathways Type II interferon signaling (IFNG)
Spinal Cord Injury
AGE/RAGE pathway
Effects of Nitric Oxide
References
Ref 468175(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5111).
Ref 534283Br J Pharmacol. 1996 Nov;119(6):1101-8.2-Amino-4-methylpyridine as a potent inhibitor of inducible NO synthase activity in vitro and in vivo.

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