Drug Information

Drug General Information
Drug ID
D0O3FX
Former ID
DNC003463
Drug Name
NU1025
Drug Type
Small molecular drug
Indication Discovery agent Terminated [546083]
Structure
Download
2D MOL

3D MOL
Formula
C9H8N2O2
Canonical SMILES
CC1=NC(=O)C2=C(N1)C(=CC=C2)O
InChI
1S/C9H8N2O2/c1-5-10-8-6(9(13)11-5)3-2-4-7(8)12/h2-4,12H,1H3,(H,10,11,13)
InChIKey
YJDAOHJWLUNFLX-UHFFFAOYSA-N
CAS Number
CAS 90417-38-2
PubChem Compound ID
63306
PubChem Substance ID
525179, 5459250, 7714724, 7889500, 11114066, 11438831, 14748258, 24630592, 24724555, 26718998, 26759282, 43120311, 46394389, 46508590, 53800626, 56387608, 57314998, 60750176, 79684545, 85789027, 91613754, 103355511, 103962966, 104327985, 125609675, 126637993, 126671678, 129803250, 131329868, 132556610, 134342467, 134964494, 135020379, 137245102, 142522811, 143493396, 144116288, 152241193, 160965866, 162022870, 163136985, 163414793, 163687569, 164175029, 164758049, 174554812, 184538758, 202827486, 208264843, 211786567
Target and Pathway
Target(s) Poly [ADP-ribose] polymerase-1 Target Info Inhibitor [551374]
KEGG Pathway Base excision repair
NF-kappa B signaling pathway
PANTHER Pathway FAS signaling pathway
Pathway Interaction Database Integrin-linked kinase signaling
Caspase Cascade in Apoptosis
Notch-mediated HES/HEY network
Reactome Dual Incision in GG-NER
WikiPathways FAS pathway and Stress induction of HSP regulation
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
Nanoparticle triggered regulated necrosis
Corticotropin-releasing hormone
References
Ref 546083Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006270)
Ref 551374The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.

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