Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0O2YE
|
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| Former ID |
DNC000745
|
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| Drug Name |
HTF 919
|
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| Drug Type |
Small molecular drug
|
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| Indication | Constipation [ICD9: 564; ICD10:K59.0] | Approved | [1], [2] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C16H23N5O
|
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| Canonical SMILES |
CCCCCN=C(N)NNC=C1C=NC2=C1C=C(C=C2)CO
|
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| InChI |
1S/C16H23N5O/c1-2-3-4-7-18-16(17)21-20-10-13-9-19-15-6-5-12(11-22)8-14(13)15/h5-6,8-10,20,22H,2-4,7,11H2,1H3,(H3,17,18,21)/b13-10+
|
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| InChIKey |
URPUECXJHQGUDU-JLHYYAGUSA-N
|
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| CAS Number |
CAS 189188-57-6
|
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| ChEBI ID |
ChEBI:51044
|
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| SuperDrug ATC ID |
N06BA01
|
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| SuperDrug CAS ID |
cas=000300629
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| Target and Pathway | |||||
| Target(s) | 5-hydroxytryptamine 4 receptor | Target Info | Agonist | [3] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| cAMP signaling pathway | |||||
| Neuroactive ligand-receptor interaction | |||||
| Serotonergic synapse | |||||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| 5HT4 type receptor mediated signaling pathway | |||||
| PathWhiz Pathway | Excitatory Neural Signalling Through 5-HTR 4 and Serotonin | ||||
| Reactome | Serotonin receptors | ||||
| G alpha (s) signalling events | |||||
| WikiPathways | Serotonin Receptor 4/6/7 and NR3C Signaling | ||||
| Monoamine GPCRs | |||||
| GPCRs, Class A Rhodopsin-like | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006410) | ||||
| REF 2 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | ||||
| REF 3 | 5-Hydroxytryptamine mediated contractions in isolated preparations of equine ileum and pelvic flexure: pharmacological characterization of a new 5-HT(4) agonist. J Vet Pharmacol Ther. 2002 Feb;25(1):49-58. | ||||
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