Drug Information

Drug General Information
Drug ID
D0O2ET
Former ID
DIB004395
Drug Name
AD-5467
Synonyms
Rac-2,8-Bis(1-methylethyl)-3-thioxo-2,3-dihydro-4H-1,4-benzoxazine-4-acetic acid
Drug Type
Small molecular drug
Indication Diabetes [ICD9: 253.5, 588.1; ICD10:E23.2, N25.1] Discontinued in Phase 2 [544842]
Structure
Download
2D MOL

3D MOL
Formula
C16H21NO3S
Canonical SMILES
CC(C)C1C(=S)N(C2=CC=CC(=C2O1)C(C)C)CC(=O)O
InChI
1S/C16H21NO3S/c1-9(2)11-6-5-7-12-15(11)20-14(10(3)4)16(21)17(12)8-13(18)19/h5-7,9-10,14H,8H2,1-4H3,(H,18,19)
InChIKey
CLDJCRWXLDLJLO-UHFFFAOYSA-N
CAS Number
CAS 112808-22-7
PubChem Compound ID
197383
PubChem Substance ID
3281748, 5113092, 10262406, 11397918, 12014154, 14752031, 33517281, 50121396, 77438448, 83123730, 85817751, 89757883, 92275200, 103420351, 103972794, 113465129, 125532385, 127641116, 135175472, 137144712, 139060522, 139839834, 162370014, 162476366, 224118452, 227452436
Target and Pathway
Target(s) Aldose reductase Target Info Inhibitor [531314], [551871]
BioCyc Pathway Methylglyoxal degradation III
Acetone degradation I (to methylglyoxal)
KEGG Pathway Pentose and glucuronate interconversions
Fructose and mannose metabolism
Galactose metabolism
Glycerolipid metabolism
Metabolic pathways
NetPath Pathway IL1 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
PathWhiz Pathway Fructose and Mannose Degradation
Pyruvate Metabolism
Pterine Biosynthesis
Glycerolipid Metabolism
Galactose Metabolism
WikiPathways Metapathway biotransformation
Polyol Pathway
Metabolism of steroid hormones and vitamin D
References
Ref 544842Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001300)
Ref 531314Studies on antidiabetic agents. IX. A new aldose reductase inhibitor, AD-5467, and related 1,4-benzoxazine and 1,4-benzothiazine derivatives: synthesis and biological activity. Chem Pharm Bull (Tokyo). 1990 May;38(5):1238-45.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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