Drug General Information
Drug ID	D0O0PY
Former ID	DIB010195
Drug Name	Pagoclone
Synonyms	IP-456; RP-59037; RP-62955
Drug Type	Small molecular drug
Indication	Anxiety disorder [ICD9: 300, 311; ICD10:F32, F40-F42]		Phase 2/3	[522559]
Company	Rhone-Poulenc SA
Structure		Download 2D MOL 3D MOL
Formula	C23H22ClN3O2
Canonical SMILES	N1(C(=O)c2c(C1CC(=O)CCC(C)C)cccc2)c1nc2nc(ccc2cc1)Cl
CAS Number	CAS 133737-32-3
PubChem Compound ID	131664
Target and Pathway
Target(s)	GABA A receptor	Target Info	Modulator	[528204]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Retrograde endocannabinoid signaling
	GABAergic synapse
	Morphine addiction
	Nicotine addiction
Reactome	Ligand-gated ion channel transport
	GABA A receptor activation
WikiPathways	SIDS Susceptibility Pathways
	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	Iron uptake and transport
References
Ref 522559	ClinicalTrials.gov (NCT00830154) A Study to Assess the Efficacy and Safety of Pagoclone for Adults With Stuttering. U.S. National Institutes of Health.
Ref 528204	Evaluation of the abuse potential of pagoclone, a partial GABAA agonist. J Clin Psychopharmacol. 2006 Jun;26(3):268-73.

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