Drug General Information
Drug ID	D0NU6Y
Former ID	DIB006221
Drug Name	192C86
Synonyms	BW-192C86
Drug Type	Small molecular drug
Indication	Thrombosis [ICD9: 437.6, 453, 671.5, 671.9; ICD10:I80-I82]		Phase 1	[526857]
Company	Burroughs Wellcome Inc
Structure		Download 2D MOL 3D MOL
Formula	C20H33N3O4S
Canonical SMILES	N1(C(=O)N(C2C1CC(C2)SCCCC(=O)O)CC)/N=C/C(C1CCCCC1)O
CAS Number	CAS 139147-26-5
PubChem Compound ID	9576901
Target and Pathway
Target(s)	Prostaglandin D2 receptor	Target Info	Modulator	[544117]
KEGG Pathway	Neuroactive ligand-receptor interaction
Pathway Interaction Database	Thromboxane A2 receptor signaling
PathWhiz Pathway	Intracellular Signalling Through PGD2 receptor and Prostaglandin D2
Reactome	Prostanoid ligand receptors
	G alpha (s) signalling events
WikiPathways	Prostaglandin Synthesis and Regulation
	GPCRs, Class A Rhodopsin-like
	Small Ligand GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 526857	The effect of a prostaglandin DP-receptor partial agonist (192C86) on platelet aggregation and the cardiovascular system in healthy volunteers. Br J Clin Pharmacol. 1992 Oct;34(4):344-51.
Ref 544117	Prostanoid receptor antagonists: development strategies and therapeutic applications. Br J Pharmacol. 2009 September; 158(1): 104-145.

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