Drug Information
Drug General Information | |||||
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Drug ID |
D0ND8J
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Former ID |
DNC013745
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Drug Name |
(-)-(1S,1'R)-O,O-dimethylgrisbine hydrochloride
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Investigative | [1] | ||
Structure |
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Download2D MOL |
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Formula |
C39H47ClN2O6
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Canonical SMILES |
CN1CCC2=CC(=C(C=C2C1CC3=CC=C(C=C3)OC4=C(C=CC(=C4)CC5C6=<br />CC(=C(C=C6CCN5C)OC)OC)OC)OC)OC.Cl
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InChI |
1S/C39H46N2O6.ClH/c1-40-16-14-27-21-35(43-4)37(45-6)23-30(27)32(40)18-25-8-11-29(12-9-25)47-39-20-26(10-13-34(39)42-3)19-33-31-24-38(46-7)36(44-5)22-28(31)15-17-41(33)2;/h8-13,20-24,32-33H,14-19H2,1-7H3;1H/t32-,33+;/m1./s1
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InChIKey |
OEBMBMKSAQUFSL-VMXYRSAXSA-N
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PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | D(2) dopamine receptor | Target Info | Inhibitor | [1] | |
Dopamine D1 receptor | Target Info | Inhibitor | [1] | ||
KEGG Pathway | Rap1 signaling pathway | ||||
cAMP signaling pathway | |||||
Neuroactive ligand-receptor interaction | |||||
Gap junction | |||||
Dopaminergic synapse | |||||
Parkinson's disease | |||||
Cocaine addiction | |||||
Alcoholismhsa04020:Calcium signaling pathway | |||||
Amphetamine addiction | |||||
Morphine addiction | |||||
Alcoholism | |||||
PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | |||||
Dopamine receptor mediated signaling pathway | |||||
Nicotine pharmacodynamics pathwayP05912:Dopamine receptor mediated signaling pathway | |||||
PathWhiz Pathway | Dopamine Activation of Neurological Reward System | ||||
Reactome | Dopamine receptors | ||||
G alpha (i) signalling eventsR-HSA-390651:Dopamine receptors | |||||
G alpha (s) signalling events | |||||
WikiPathways | Hypothetical Network for Drug Addiction | ||||
Monoamine GPCRs | |||||
GPCRs, Class A Rhodopsin-like | |||||
Genes and (Common) Pathways Underlying Drug Addiction | |||||
GPCR ligand binding | |||||
GPCR downstream signaling | |||||
Nicotine Activity on Dopaminergic NeuronsWP666:Hypothetical Network for Drug Addiction | |||||
References | |||||
REF 1 | Displacement activity of bisbenzylisoquinoline alkaloids at striatal 3H-SCH 23390 and 3H-raclopride binding sites. J Nat Prod. 1992 Sep;55(9):1281-6. | ||||
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