Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0NC1D
|
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| Former ID |
DIB000468
|
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| Drug Name |
MX-6120
|
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| Synonyms |
MX-6120; Endothelin-1 antagonists (heart disease); ET-1 antagonists (heart disease), Maxia; Endothelin-1 antagonists (heart disease), Maxia
|
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| Indication | Heart disease [ICD9: 390-429; ICD10:I00-I52] | Terminated | [1] | ||
| Company |
Maxia Pharmaceuticals Inc
|
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| Target and Pathway | |||||
| Target(s) | Endothelin-1 receptor | Target Info | Antagonist | [2] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| cGMP-PKG signaling pathway | |||||
| cAMP signaling pathway | |||||
| Neuroactive ligand-receptor interaction | |||||
| Vascular smooth muscle contraction | |||||
| Renin secretion | |||||
| Pathways in cancer | |||||
| NetPath Pathway | IL4 Signaling Pathway | ||||
| PANTHER Pathway | Endothelin signaling pathway | ||||
| Pathway Interaction Database | Endothelins | ||||
| EGFR-dependent Endothelin signaling events | |||||
| Reactome | Peptide ligand-binding receptors | ||||
| G alpha (q) signalling events | |||||
| WikiPathways | Prostaglandin Synthesis and Regulation | ||||
| GPCRs, Class A Rhodopsin-like | |||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| Peptide GPCRs | |||||
| Endothelin Pathways | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| GPCRs, Other | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800018158) | ||||
| REF 2 | Endothelin receptor antagonists in heart failure: current status and future directions. Drugs. 2004;64(10):1029-40. | ||||
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