Drug Information

Drug General Information
Drug ID
D0NB4Q
Former ID
DIB018453
Drug Name
10-OBn-7alpha-F-gingkolide B
Synonyms
compound 17 [PMID: 12570381]
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539143]
Structure
Download
2D MOL
Formula
C27H29FO10
InChI
InChI=1S/C27H29FO10/c1-11-19(30)35-17-15(29)25-16-13(28)14(23(2,3)4)24(25)18(34-10-12-8-6-5-7-9-12)20(31)37-22(24)38-27(25,21(32)36-16)26(11,17)33/h5-9,11,13-18,22,29,33H,10H2,1-4H3/t11?,13-,14?,15?,16?,17-,18-,22?,24?,25?,26+,27-/m0/s1
InChIKey
LFVHCLPCEWRXME-CLNXZACASA-N
PubChem Compound ID
73755010
PubChem Substance ID
135652650
Target and Pathway
Target(s) Platelet-activating factor receptor Target Info Antagonist [526536]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Staphylococcus aureus infection
NetPath Pathway IL5 Signaling Pathway
Leptin Signaling Pathway
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
Interferon gamma signaling
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Small Ligand GPCRs
Interferon gamma signaling
GPCR ligand binding
GPCR downstream signaling
References
Ref 539143(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1835).
Ref 526536Preparation of 7-substituted ginkgolide derivatives: potent platelet activating factor (PAF) receptor antagonists. J Med Chem. 2003 Feb 13;46(4):601-8.

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