Drug Information
Drug General Information | |||||
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Drug ID |
D0N9GI
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Former ID |
DNC000526
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Drug Name |
DDAVP
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Drug Type |
Small molecular drug
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Indication | Diabetes [ICD9: 253.5, 588.1; ICD10:E23.2, N25.1] | Approved | [522431] | ||
Structure |
Download2D MOL |
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Formula |
C46H64N14O12S2
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Canonical SMILES |
C1CC(N(C1)C(=O)C2CSSCCC(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C<br />(=O)N2)CC(=O)N)CCC(=O)N)CC3=CC=CC=C3)CC4=CC=C(C=C4)O)C(<br />=O)NC(CCCN=C(N)N)C(=O)NCC(=O)N
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InChI |
1S/C46H64N14O12S2/c47-35(62)15-14-29-40(67)58-32(22-36(48)63)43(70)59-33(45(72)60-18-5-9-34(60)44(71)56-28(8-4-17-52-46(50)51)39(66)53-23-37(49)64)24-74-73-19-16-38(65)54-30(21-26-10-12-27(61)13-11-26)41(68)57-31(42(69)55-29)20-25-6-2-1-3-7-25/h1-3,6-7,10-13,28-34,61H,4-5,8-9,14-24H2,(H2,47,62)(H2,48,63)(H2,49,64)(H,53,66)(H,54,65)(H,55,69)(H,56,71)(H,57,68)(H,58,67)(H,59,70)(H4,50,51,52)
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InChIKey |
NFLWUMRGJYTJIN-UHFFFAOYSA-N
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CAS Number |
CAS 302-40-9
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PubChem Compound ID | |||||
PubChem Substance ID | |||||
Target and Pathway | |||||
Target(s) | Vasopressin V2 receptor | Target Info | Agonist | [535006], [536397], [537856], [537914] | |
Pathway Interaction Database | Arf6 trafficking events | ||||
PathWhiz Pathway | Vasopressin Regulation of Water Homeostasis | ||||
References | |||||
Ref 535006 | Vasopressin-induced von Willebrand factor secretion from endothelial cells involves V2 receptors and cAMP. J Clin Invest. 2000 Jul;106(1):107-16. | ||||
Ref 536397 | Hydronephrosis: prevention by restoration of urinary concentrating ability using desamino-8D-arginine vasopressin (DDAVP) in Brattleboro rats. Int J Exp Pathol. 1991 Oct;72(5):581-7. | ||||
Ref 537856 | An extracellular residue determines the agonist specificity of V2 vasopressin receptors. FEBS Lett. 1995 Mar 27;362(1):19-23. | ||||
Ref 537914 | The abnormal quinine drinking aversion in the Brattleboro rat with diabetes insipidus is reversed by the vasopressin agonist DDAVP: a possible role for vasopressin in the motivation to drink. PhysiolBehav. 1994 Mar;55(3):407-12. |
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