| Drug General Information |
| Drug ID |
D0N8YG
|
| Former ID |
DNC006059
|
| Drug Name |
1-((S)-2-aminopropyl)-7-methyl-1H-indazol-6-ol
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C11H15N3O
|
| Canonical SMILES |
CC1=C2C(=CNN2CC(C)N)C=CC1=O
|
| InChI |
1S/C11H15N3O/c1-7(12)6-14-11-8(2)10(15)4-3-9(11)5-13-14/h3-5,7,13H,6,12H2,1-2H3
|
| InChIKey |
MIBVBASXMOZOBF-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
5-hydroxytryptamine 2C receptor |
Target Info |
Inhibitor |
[1]
|
|---|
| 5-hydroxytryptamine 2B receptor |
Target Info |
Inhibitor |
[1]
|
| 5-hydroxytryptamine 2A receptor |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
|
Calcium signaling pathway
|
|
Neuroactive ligand-receptor interaction
|
|
Gap junction
|
|
Serotonergic synapse
|
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Inflammatory mediator regulation of TRP channelshsa04020:Calcium signaling pathway
|
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Inflammatory mediator regulation of TRP channels
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PANTHER Pathway
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5HT2 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathway
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Reactome
|
Serotonin receptors
|
|
G alpha (q) signalling eventsR-HSA-390666:Serotonin receptors
|
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G alpha (q) signalling events
|
|
WikiPathways
|
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
|
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Monoamine GPCRs
|
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GPCRs, Class A Rhodopsin-like
|
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Gastrin-CREB signalling pathway via PKC and MAPK
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GPCR ligand binding
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GPCR downstream signalingWP732:Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
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GPCR downstream signalingWP733:Serotonin Receptor 2 and STAT3 Signaling
|
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SIDS Susceptibility Pathways
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|
GPCR downstream signaling
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|
GPCRs, Other
|
| References |
| REF 1 | J Med Chem. 2006 Jan 12;49(1):318-28.1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity. |
|---|
