Drug General Information
Drug ID	D0N8UY
Former ID	DIB010148
Drug Name	LY-686017
Synonyms	NK1 antagonist (anxiety/alcoholism), Eli Lilly
Drug Type	Small molecular drug
Indication	Alcohol use disorders [ICD9: 303; ICD10:F10.2]		Phase 2	[521696]
Company	Eli Lilly & Co
Structure		Download 2D MOL 3D MOL
Formula	C28H16ClF6N5O
Canonical SMILES	c1(c(n(nn1)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccncc1)c1c(C<br />(=O)c2c(Cl)cccc2)cccn1
PubChem Compound ID	9916461
Target and Pathway
Target(s)	Substance-P receptor	Target Info	Antagonist	[544119]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Measles
PANTHER Pathway	CCKR signaling map ST
Reactome	G alpha (q) signalling events
WikiPathways	SIDS Susceptibility Pathways
	Gastrin-CREB signalling pathway via PKC and MAPK
	Spinal Cord Injury
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 521696	ClinicalTrials.gov (NCT00191022) Comparison of LY686017 With a Marketed Drug in the Treatment of Social Anxiety Disorder. U.S. National Institutes of Health.
Ref 544119	Stress-related neuropeptides and alcoholism: CRH, NPY and beyond. Alcohol. 2009 November; 43(7): 491-498.

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