Drug Information

Drug General Information
Drug ID
D0N8UD
Former ID
DNC010848
Drug Name
2,2,2-TRIFLUORO-1-(4-FLUOROPHENYL)-1-(1-(4-FLUOROPHENYL)-1H-INDAZOL-5-YL)ETHANOL (DIASTEREOMERIC MIX)
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530879]
Structure
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2D MOL

3D MOL
Formula
C21H13F5N2O
Canonical SMILES
C1=CC(=CC=C1C(C2=CC3=C(C=C2)N(N=C3)C4=CC=C(C=C4)F)(C(F)<br />(F)F)O)F
InChI
1S/C21H13F5N2O/c22-16-4-1-14(2-5-16)20(29,21(24,25)26)15-3-10-19-13(11-15)12-27-28(19)18-8-6-17(23)7-9-18/h1-12,29H
InChIKey
KMBFENZTPAWDBF-UHFFFAOYSA-N
PubChem Compound ID
46888391
Target and Pathway
Target(s) mRNA of glucocorticoid receptor Target Info Inhibitor [530879]
KEGG Pathway Neuroactive ligand-receptor interaction
NetPath Pathway IL2 Signaling Pathway
TCR Signaling Pathway
Pathway Interaction Database Regulation of nuclear SMAD2/3 signaling
Signaling events mediated by HDAC Class II
FOXA2 and FOXA3 transcription factor networks
Glucocorticoid receptor regulatory network
Regulation of Androgen receptor activity
AP-1 transcription factor network
Reactome BMAL1:CLOCK,NPAS2 activates circadian gene expression
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
SIDS Susceptibility Pathways
Endoderm Differentiation
Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
Adipogenesis
Circadian Clock
Nuclear Receptors
References
Ref 530879Bioorg Med Chem Lett. 2010 May 15;20(10):3017-20. Epub 2010 Apr 11.5-Functionalized indazoles as glucocorticoid receptor agonists.
Ref 530879Bioorg Med Chem Lett. 2010 May 15;20(10):3017-20. Epub 2010 Apr 11.5-Functionalized indazoles as glucocorticoid receptor agonists.

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