Drug General Information
Drug ID	D0N8JP
Former ID	DIB001851
Drug Name	JTV-803
Drug Type	Small molecular drug
Indication	Thrombosis [ICD9: 437.6, 453, 671.5, 671.9; ICD10:I80-I82]		Discontinued in Phase 1	[1]
Company	Japan Tobacco Inc
Structure		Download 2D MOL 3D MOL
Formula	C23H31N5O6S
Canonical SMILES	S(=O)(=O)(O)C.N1(C(=N)N)Cc2c(cc(OCC3(C(=O)O)CCN(c4ccncc<br />4)CC3)cc2)CC1
CAS Number	CAS 247131-79-9
PubChem Compound ID	11432124
Target and Pathway
Target(s)	Coagulation factor Xa	Target Info	Inhibitor	[2], [3]
KEGG Pathway	Complement and coagulation cascades
PANTHER Pathway	Blood coagulation
Pathway Interaction Database	Beta2 integrin cell surface interactions
PathWhiz Pathway	Coagulation
Reactome	Extrinsic Pathway of Fibrin Clot Formation
	Intrinsic Pathway of Fibrin Clot Formation
	Common Pathway of Fibrin Clot Formation
	Gamma-carboxylation of protein precursors
	Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
	Removal of aminoterminal propeptides from gamma-carboxylated proteins
WikiPathways	Complement and Coagulation Cascades
	Human Complement System
	PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
	Blood Clotting Cascade
	Formation of Fibrin Clot (Clotting Cascade)
References
REF 1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800014748)
REF 2	Venous thromboembolism in the patient with cancer: focus on burden of disease and benefits of thromboprophylaxis. Cancer. 2011 Apr 1;117(7):1334-49.
REF 3	Semuloparin for the prevention of venous thromboembolic events in cancer patients. Drugs Today (Barc). 2012 Jul;48(7):451-7.

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