Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0N7QP
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| Former ID |
DIB006713
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| Drug Name |
NO-antihypertensives
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| Synonyms |
NCX-899; NCX-900; NO donor ACE inhibitors (hypertension), NicOx/Merck & Co; NO-antihypertensives, NicOx/Merck & Co; NO-enalapril (hypertension), NicOx/Merck & Co
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| Indication | Hypertension [ICD9: 401; ICD10:I10-I16] | Terminated | [1] | ||
| Company |
NicOx SA
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| Structure |
|
Download2D MOL |
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| Canonical SMILES |
N1(C(=O)[C@@H](N[C@H](C(=O)OCC)CCc2ccccc2)C)[C@H](C(=O)<br />OCCCO[N+](=O)[O-])CCC1.C(=C\C(=O)O)\C(=O)O
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| Target and Pathway | |||||
| Target(s) | Angiotensin-converting enzyme | Target Info | Inhibitor | [2] | |
| KEGG Pathway | Renin-angiotensin system | ||||
| Chagas disease (American trypanosomiasis) | |||||
| Hypertrophic cardiomyopathy (HCM) | |||||
| PathWhiz Pathway | Angiotensin Metabolism | ||||
| Reactome | Metabolism of Angiotensinogen to Angiotensins | ||||
| WikiPathways | ACE Inhibitor Pathway | ||||
| Metabolism of Angiotensinogen to Angiotensins | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010971) | ||||
| REF 2 | Molecular determinants of cAMP-mediated regulation of the Na+-Ca2+ exchanger expressed in human cell lines. J Physiol. 2003 May 1; 548(Pt 3): 677-689. | ||||
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