Drug General Information
Drug ID
D0N7MS
Former ID
DIB018743
Drug Name
ACAA
Synonyms
ACA
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539571]
Structure
Download
2D MOL
Formula
C21H23NO3
InChI
InChI=1S/C21H23NO3/c1-2-3-4-7-16-10-12-17(13-11-16)14-15-20(23)22-19-9-6-5-8-18(19)21(24)25/h5-6,8-15H,2-4,7H2,1H3,(H,22,23)(H,24,25)/b15-14+
InChIKey
GAMRBCZMOOMBSQ-CCEZHUSRSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) TRPM8 protein Target Info Blocker (channel blocker) [543859]
Short transient receptor potential channel 6 Target Info Blocker (channel blocker) [543855]
Long transient receptor potential channel 2 Target Info Blocker (channel blocker) [528125]
Short transient receptor potential channel 3 Target Info Blocker (channel blocker) [543852]
KEGG Pathway Inflammatory mediator regulation of TRP channels
PANTHER Pathway Alzheimer disease-presenilin pathway
Pathway Interaction Database Endothelins
Nephrin/Neph1 signaling in the kidney podocyte
EPO signaling pathway
PAR1-mediated thrombin signaling eventspi3kplctrkpathway:Trk receptor signaling mediated by PI3K and PLC-gamma
Reactome TRP channelsR-HSA-114508:Effects of PIP2 hydrolysis
TRP channels
Role of second messengers in netrin-1 signalingR-HSA-3295583:TRP channelsR-HSA-114508:Effects of PIP2 hydrolysis
Role of second messengers in netrin-1 signaling
WikiPathways Primary Focal Segmental Glomerulosclerosis FSGS
Platelet homeostasis
Netrin-1 signaling
GPCR downstream signaling
Effects of PIP2 hydrolysisWP1885:Platelet homeostasis
Effects of PIP2 hydrolysis
References
Ref 539571(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2443).
Ref 528125Inhibition of TRPM2 cation channels by N-(p-amylcinnamoyl)anthranilic acid. Br J Pharmacol. 2006 Jun;148(3):264-73.
Ref 543852(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 488).
Ref 543855(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 491).
Ref 543859(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 500).

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.