| Drug General Information |
| Drug ID |
D0N7HY
|
| Former ID |
DIB020623
|
| Drug Name |
Org 12962
|
| Synonyms |
Org-12962; Org12962
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
|
| Formula |
C10H11ClF3N3
|
| InChI |
InChI=1S/C10H11ClF3N3/c11-9-7(10(12,13)14)1-2-8(16-9)17-5-3-15-4-6-17/h1-2,15H,3-6H2
|
| InChIKey |
QZYYPQAYSFBKPW-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
14848193, 24106295, 44832418, 50076970, 78818513, 85212004, 93816413, 103604038, 109620386, 124758392, 125432844, 126732500, 129099331, 134480425, 135580112, 135650777, 136351633, 137000416, 137144107, 139711519, 143471802, 160822611, 162049884, 162118603, 162301771, 162473604, 163382414, 165816001, 174546216, 187576417, 203092652, 223595679, 223657866, 227172108, 250203462, 252493275
|
| Target and Pathway |
| Target(s) |
5-hydroxytryptamine 2C receptor |
Target Info |
Agonist |
[2]
|
|---|
| 5-hydroxytryptamine 2A receptor |
Target Info |
Agonist |
[2]
|
| 5-hydroxytryptamine 2B receptor |
Target Info |
Agonist |
[2]
|
|
KEGG Pathway
|
Calcium signaling pathway
|
|
Neuroactive ligand-receptor interaction
|
|
Gap junction
|
|
Serotonergic synapse
|
|
Inflammatory mediator regulation of TRP channelshsa04020:Calcium signaling pathway
|
|
Inflammatory mediator regulation of TRP channels
|
|
PANTHER Pathway
|
5HT2 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathway
|
|
Reactome
|
Serotonin receptors
|
|
G alpha (q) signalling eventsR-HSA-390666:Serotonin receptors
|
|
G alpha (q) signalling events
|
|
WikiPathways
|
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
|
|
Monoamine GPCRs
|
|
GPCRs, Class A Rhodopsin-like
|
|
Gastrin-CREB signalling pathway via PKC and MAPK
|
|
GPCR ligand binding
|
|
GPCR downstream signalingWP733:Serotonin Receptor 2 and STAT3 Signaling
|
|
SIDS Susceptibility Pathways
|
|
GPCR downstream signaling
|
|
GPCRs, OtherWP732:Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
|
| References |
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 170). |
|---|
| REF 2 | Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors. Naunyn Schmiedebergs Arch Pharmacol. 2004 Aug;370(2):114-23. Epub 2004 Jul 30. |
|---|
