Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0N6AY
|
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| Former ID |
DIB020561
|
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| Drug Name |
norfenfluramine
|
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| Synonyms |
(+/-)-norfenfluramine
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C10H12F3N
|
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| InChI |
InChI=1S/C10H12F3N/c1-7(14)5-8-3-2-4-9(6-8)10(11,12)13/h2-4,6-7H,5,14H2,1H3
|
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| InChIKey |
MLBHFBKZUPLWBD-UHFFFAOYSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID |
97531, 4311739, 8161939, 10511817, 11408389, 15171750, 29283810, 50004686, 57329182, 80908838, 85229952, 92729750, 104338397, 104709389, 117504762, 125661955, 125817937, 125818179, 128611223, 134979371, 135060646, 135650839, 136352336, 137009512, 162222968, 163240656, 170539124, 177749656, 179236047, 184594615, 184594616, 216088146, 224777341, 226429099, 242517762, 249910978, 252347921
|
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| Target and Pathway | |||||
| Target(s) | 5-hydroxytryptamine 2B receptor | Target Info | Agonist | [2] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Gap junction | |||||
| Serotonergic synapse | |||||
| Inflammatory mediator regulation of TRP channels | |||||
| PANTHER Pathway | 5HT2 type receptor mediated signaling pathway | ||||
| Reactome | Serotonin receptors | ||||
| G alpha (q) signalling events | |||||
| WikiPathways | Serotonin Receptor 2 and ELK-SRF/GATA4 signaling | ||||
| Monoamine GPCRs | |||||
| GPCRs, Class A Rhodopsin-like | |||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 215). | ||||
| REF 2 | Evidence for possible involvement of 5-HT(2B) receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications. Circulation. 2000 Dec 5;102(23):2836-41. | ||||
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