Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0N5JJ
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| Former ID |
DIB016885
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| Drug Name |
ADROGOLIDE HYDROCHLORIDE
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| Synonyms |
ABT-431; Adrogolide hydrochloride < USAN; DAS-431; Prop INNM >; A-93431.1; 9,10-Diacetoxy-2-propyl-4,5,5a(R),6,7,11b(S)-hexahydrobenzo[f]thieno[2,3-c]quinoline hydrochloride
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| Drug Type |
Small molecular drug
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| Indication | Cognitive disorders [ICD9: 290-294, 294.0, 780.09, 780.9, 780.93; ICD10:F01-F07, F04, F05, R41.3] | Discontinued in Phase 2 | [1] | ||
| Structure |
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Download2D MOL |
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| Formula |
C22H26ClNO4S
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| Canonical SMILES |
CCCc1cc2[C@H]3[C@@H](CCc4cc(OC(=O)C)c(OC(=O)C)cc34)NCc2<br />s1
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| InChI |
1S/C22H25NO4S/c1-4-5-15-9-17-21(28-15)11-23-18-7-6-14-8-19(26-12(2)24)20(27-13(3)25)10-16(14)22(17)18/h8-10,18,22-23H,4-7,11H2,1-3H3/t18-,22+/m1/s1
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| InChIKey |
KTEBZVJGMARTOQ-GCJKJVERSA-N
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| CAS Number |
CAS 166591-11-3
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Dopamine D1 receptor | Target Info | Agonist | [2], [3] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| cAMP signaling pathway | |||||
| Neuroactive ligand-receptor interaction | |||||
| Gap junction | |||||
| Dopaminergic synapse | |||||
| Parkinson's disease | |||||
| Cocaine addiction | |||||
| Amphetamine addiction | |||||
| Morphine addiction | |||||
| Alcoholism | |||||
| PANTHER Pathway | Dopamine receptor mediated signaling pathway | ||||
| PathWhiz Pathway | Dopamine Activation of Neurological Reward System | ||||
| Reactome | Dopamine receptors | ||||
| G alpha (s) signalling events | |||||
| WikiPathways | Hypothetical Network for Drug Addiction | ||||
| Monoamine GPCRs | |||||
| GPCRs, Class A Rhodopsin-like | |||||
| Genes and (Common) Pathways Underlying Drug Addiction | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006590) | ||||
| REF 2 | Adrogolide HCl (ABT-431; DAS-431), a prodrug of the dopamine D1 receptor agonist, A-86929: preclinical pharmacology and clinical data. CNS Drug Rev. 2001 Fall;7(3):305-16. | ||||
| REF 3 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | ||||
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