Drug Information

Drug General Information
Drug ID
D0N5HJ
Former ID
DAP001374
Drug Name
Enalaprilat
Synonyms
EAL; Enalaprilate; Enalaprilatum; ENALAPRILAT INHIBITOR; Enalapril acid; Enalapril diacid; Enalaprilat anhydrous; Enalaprilic acid; Enalprilat hydrate; Enalprilate hydrate; Enalaprilat (USP); MK-422; Renitec (TN); Vasotec (TN); Vasotec I.V.; N-[(1S)-1-carboxy-3-phenylpropyl]-L-alanyl-L-proline; N-[(1S)-1-carboxy-3-phenylpropyl]-L-alanyl-L-proline-water (1/2); (2S)-1-[(2S)-2-[[(2S)-1-hydroxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]pyrrolidine-2-carboxylic acid; (2S)-1-[(2S)-2-[[(2S)-1-hydroxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]pyrrolidine-2-carboxylic acid dihydrate; 1-((2S)-2-{[(1S)-1-CARBOXY-3-PHENYLPROPYL]AMINO}PROPANOYL)-L-PROLINE; 1-(N-((S)-1-Carboxy-3-phenylpropyl)-L-alanyl)-L-proline dihydrate
Drug Type
Small molecular drug
Indication Hypertension [ICD9: 401; ICD10:I10-I16] Approved [536361], [541478]
Therapeutic Class
Antihypertensive Agents
Company
Merck & Co
Structure
Download
2D MOL

3D MOL
Formula
C18H24N2O5
InChI
InChI=1S/C18H24N2O5/c1-12(16(21)20-11-5-8-15(20)18(24)25)19-14(17(22)23)10-9-13-6-3-2-4-7-13/h2-4,6-7,12,14-15,19H,5,8-11H2,1H3,(H,22,23)(H,24,25)/t12-,14-,15-/m0/s1
InChIKey
LZFZMUMEGBBDTC-QEJZJMRPSA-N
CAS Number
CAS 76420-72-9
PubChem Compound ID
5462501
PubChem Substance ID
13885, 7887268, 11688562, 14876097, 14900718, 26719866, 26758015, 39459536, 46386741, 49681611, 50070755, 50466382, 92308386, 92308980, 93166910, 93311012, 93577953, 99313641, 103179234, 104253291, 114004069, 118313442, 121362057, 124659029, 124757412, 124800027, 125164216, 126650398, 128562671, 131325846, 134221872, 135012534, 137024395, 143297080, 144076246, 151979549, 152031989, 160661062, 160846356, 162176890, 162262134, 163564990, 164786777, 165698333, 172080415, 172913628, 175266379, 176484234, 176484707, 178102950
Target and Pathway
Target(s) Angiotensin-converting enzyme Target Info Inhibitor [535379]
KEGG Pathway Renin-angiotensin system
Chagas disease (American trypanosomiasis)
Hypertrophic cardiomyopathy (HCM)
PathWhiz Pathway Angiotensin Metabolism
Reactome Metabolism of Angiotensinogen to Angiotensins
WikiPathways ACE Inhibitor Pathway
Metabolism of Angiotensinogen to Angiotensins
References
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 541478(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6332).
Ref 535379Analysis of Vancomycin in the Hindlimb Vascular Bed of the Rat. Am J Ther. 1996 Oct;3(10):681-687.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.