Drug General Information
Drug ID	D0N4VR
Former ID	DNC003785
Drug Name	5-Fluoro-3-thiophen-3-yl-quinoline
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[533862]
Structure		Download 2D MOL 3D MOL
Formula	C13H8FNS
Canonical SMILES	C1=CC2=NC=C(C=C2C(=C1)F)C3=CSC=C3
InChI	1S/C13H8FNS/c14-12-2-1-3-13-11(12)6-10(7-15-13)9-4-5-16-8-9/h1-8H
InChIKey	BEVNNTNJJJWQAK-UHFFFAOYSA-N
PubChem Compound ID	10421346
Target and Pathway
Target(s)	Alpha platelet-derived growth factor receptor	Target Info	Inhibitor	[533862]
KEGG Pathway	MAPK signaling pathway
	Ras signaling pathway
	Rap1 signaling pathway
	Calcium signaling pathway
	Cytokine-cytokine receptor interaction
	Endocytosis
	PI3K-Akt signaling pathway
	Focal adhesion
	Gap junction
	Regulation of actin cytoskeleton
	HTLV-I infection
	Pathways in cancer
	MicroRNAs in cancer
	Glioma
	Prostate cancer
	Melanoma
	Central carbon metabolism in cancer
	Choline metabolism in cancer
NetPath Pathway	TGF_beta_Receptor Signaling Pathway
PANTHER Pathway	Angiogenesis
	PDGF signaling pathway
Pathway Interaction Database	ATF-2 transcription factor network
	PDGFR-alpha signaling pathway
	PDGF receptor signaling network
Reactome	PIP3 activates AKT signaling
	Constitutive Signaling by Aberrant PI3K in Cancer
	RAF/MAP kinase cascade
WikiPathways	Regulation of Actin Cytoskeleton
	Osteoblast Signaling
	Focal Adhesion
	Hair Follicle Development: Organogenesis (Part 2 of 3)
	PIP3 activates AKT signaling
	Cardiac Progenitor Differentiation
	Integrated Pancreatic Cancer Pathway
	Allograft Rejection
	Signaling Pathways in Glioblastoma
	Signaling by PDGF
	Angiogenesis
References
Ref 533862	J Med Chem. 1994 Jul 8;37(14):2129-37.A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives.
Ref 533862	J Med Chem. 1994 Jul 8;37(14):2129-37.A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.