Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0N2WK
|
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| Former ID |
DIB019668
|
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| Drug Name |
CV-3988
|
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| Synonyms |
CV 3988; CV3988
|
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C28H53N2O7PS
|
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| InChI |
InChI=1S/C28H53N2O7PS/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-29-28(31)35-24-27(34-2)25-37-38(32,33)36-22-20-30-21-23-39-26-30/h21,23,26-27H,3-20,22,24-25H2,1-2H3,(H-,29,31,32,33)
|
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| InChIKey |
NMHKTASGTFXJPL-UHFFFAOYSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID |
10234383, 12013001, 14911658, 17405616, 24278829, 44436655, 50065317, 50106962, 50111231, 53778166, 57338181, 74605260, 85230979, 90340573, 92303175, 103119908, 103225045, 103919472, 104379471, 117576833, 124750208, 124879724, 126431481, 135062669, 135727620, 163110452, 163565014, 178102700, 179293951, 234184627
|
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| Target and Pathway | |||||
| Target(s) | Platelet-activating factor receptor | Target Info | Antagonist | [2] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Staphylococcus aureus infection | |||||
| NetPath Pathway | IL5 Signaling Pathway | ||||
| Leptin Signaling Pathway | |||||
| Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
| G alpha (q) signalling events | |||||
| Interferon gamma signaling | |||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| Small Ligand GPCRs | |||||
| Interferon gamma signaling | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6079). | ||||
| REF 2 | Inhibition by CV-3988 of the binding of [3H]-platelet activating factor (PAF) to the platelet. Biochem Pharmacol. 1985 May 1;34(9):1491-5. | ||||
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