Drug Information

Drug General Information
Drug ID
D0N1XD
Former ID
DNC000693
Drug Name
Gliotoxin
Drug Type
Small molecular drug
Indication Discovery agent Terminated [546081]
Structure
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2D MOL

3D MOL
Formula
C13H14N2O4S2
Canonical SMILES
CN1C(=O)C23CC4=CC=CC(C4N2C(=O)C1(SS3)CO)O
InChI
1S/C13H14N2O4S2/c1-14-10(18)12-5-7-3-2-4-8(17)9(7)15(12)11(19)13(14,6-16)21-20-12/h2-4,8-9,16-17H,5-6H2,1H3/t8-,9-,12+,13+/m0/s1
InChIKey
FIVPIPIDMRVLAY-RBJBARPLSA-N
PubChem Compound ID
6223
PubChem Substance ID
12778, 632794, 8153906, 14850803, 17434293, 26756855, 26758849, 29225221, 47515432, 48334622, 49965037, 50111456, 53787166, 57323270, 57570865, 75648644, 92310145, 99301057, 103349344, 104024947, 104311454, 119503514, 121379934, 123124682, 124633173, 124633913, 127853583, 134971041, 135610149, 137156429, 162221882, 163687995, 184021220, 184533141, 184573996, 226437463, 241113133, 241180530, 241376044, 252156672, 252350184, 252455869
Target and Pathway
Target(s) Nuclear factor NF-kappa-B Target Info Inhibitor [536946]
KEGG Pathway MAPK signaling pathway
NF-kappa B signaling pathway
Osteoclast differentiation
Legionellosis
HTLV-I infection
Epstein-Barr virus infection
Pathways in cancer
Viral carcinogenesis
NetPath Pathway IL5 Signaling Pathway
PANTHER Pathway Apoptosis signaling pathway
B cell activation
Inflammation mediated by chemokine and cytokine signaling pathway
T cell activation
Toll receptor signaling pathway
Pathway Interaction Database IL12-mediated signaling events
Alternative NF-kappaB pathway
PathWhiz Pathway Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
Reactome RIP-mediated NFkB activation via ZBP1
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Interleukin-1 processing
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)
IkBA variant leads to EDA-ID
Dectin-1 mediated noncanonical NF-kB signaling
NIK-->noncanonical NF-kB signaling
TRAF6 mediated NF-kB activation
WikiPathways Toll-like receptor signaling pathway
DNA Damage Response (only ATM dependent)
SIDS Susceptibility Pathways
Nuclear Receptors Meta-Pathway
Cytosolic sensors of pathogen-associated DNA
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
EBV LMP1 signaling
TNF alpha Signaling Pathway
TSLP Signaling Pathway
Neural Crest Differentiation
TWEAK Signaling Pathway
RANKL/RANK Signaling Pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
Interleukin-1 processing
Folate Metabolism
Vitamin B12 Metabolism
Selenium Micronutrient Network
Regulation of toll-like receptor signaling pathway
References
Ref 546081Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006245)
Ref 536946Gliotoxin inhibits neointimal hyperplasia after vascular injury in rats. J Vasc Res. 2009;46(4):278-89. Epub 2008 Nov 25.

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