Drug General Information
Drug ID	D0N1PA
Former ID	DIB005136
Drug Name	CGP-49823
Drug Type	Small molecular drug
Indication	Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89]		Discontinued in Phase 2	[545737]
Company	Novartis AG
Structure		Download 2D MOL 3D MOL
Formula	C31H33N3O
Canonical SMILES	N1(C(=O)c2cc(cc(c2)C)C)[C@@H](C[C@@H](NCc2c3c(ncc2)cccc<br />3)CC1)Cc1ccccc1
CAS Number	CAS 150705-88-7
PubChem Compound ID	9869033
Target and Pathway
Target(s)	Substance-P receptor	Target Info	Antagonist	[534604]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Measles
PANTHER Pathway	CCKR signaling map ST
Reactome	G alpha (q) signalling events
WikiPathways	SIDS Susceptibility Pathways
	Gastrin-CREB signalling pathway via PKC and MAPK
	Spinal Cord Injury
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 545737	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004456)
Ref 534604	The potency of the novel tachykinin receptor antagonist CGP49823 at rat and gerbil motoneurones in vitro. Eur J Pharmacol. 1998 Jan 26;342(2-3):203-8.

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