Drug Information
Drug General Information | |||||
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Drug ID |
D0N1GH
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Former ID |
DNC005719
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Drug Name |
6-(pyridin-3-yl)-2-naphthonitrile
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Investigative | [529834] | ||
Structure |
Download2D MOL |
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Formula |
C16H10N2
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Canonical SMILES |
C1=CC(=CN=C1)C2=CC3=C(C=C2)C=C(C=C3)C#N
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InChI |
1S/C16H10N2/c17-10-12-3-4-14-9-15(6-5-13(14)8-12)16-2-1-7-18-11-16/h1-9,11H
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InChIKey |
BRNSTMOAGOETDI-UHFFFAOYSA-N
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PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | Cytochrome P450 11B1, mitochondrial | Target Info | Inhibitor | [529624] | |
17 alpha-hydroxylase-C17, 20-lyase | Target Info | Inhibitor | [529834] | ||
PathWhiz Pathway | SteroidogenesisPW000045:Androgen and Estrogen Metabolism | ||||
Steroidogenesis | |||||
WikiPathways | Metapathway biotransformation | ||||
Oxidation by Cytochrome P450 | |||||
Metabolism of steroid hormones and vitamin D | |||||
Corticotropin-releasing hormoneWP702:Metapathway biotransformation | |||||
Steroid Biosynthesis | |||||
Glucocorticoid & Mineralcorticoid Metabolism | |||||
Prostate Cancer | |||||
Phase 1 - Functionalization of compounds | |||||
References | |||||
Ref 529624 | J Med Chem. 2008 Aug 28;51(16):5064-74. Epub 2008 Aug 1.Overcoming undesirable CYP1A2 inhibition of pyridylnaphthalene-type aldosterone synthase inhibitors: influence of heteroaryl derivatization onpotency and selectivity. | ||||
Ref 529834 | J Med Chem. 2008 Dec 25;51(24):8077-87.In vivo active aldosterone synthase inhibitors with improved selectivity: lead optimization providing a series of pyridine substituted 3,4-dihydro-1H-quinolin-2-one derivatives. |
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