Drug Information

Drug General Information
Drug ID
D0N0TZ
Former ID
DIB005125
Drug Name
Clopidogrel
Synonyms
PM-103; Clopidogrel (captisol-enabled); Clopidogrel (captisol-enabled), The Medicines Co; Clopidogrel (captisol-enabled, cardiovascular disease), Cydex; Clopidogrel (captisol-enabled, cardiovascular disease), Prism Pharmaceuticals
Drug Type
Small molecular drug
Indication Thrombosis [ICD9: 437.6, 453, 671.5, 671.9; ICD10:I80-I82] Approved [542158], [548841]
Company
Prism Pharmaceuticals Inc
Structure
Download
2D MOL

3D MOL
Formula
C16H16ClNO2S
InChI
InChI=1S/C16H16ClNO2S/c1-20-16(19)15(12-4-2-3-5-13(12)17)18-8-6-14-11(10-18)7-9-21-14/h2-5,7,9,15H,6,8,10H2,1H3/t15-/m0/s1
InChIKey
GKTWGGQPFAXNFI-HNNXBMFYSA-N
PubChem Compound ID
60606
PubChem Substance ID
7978975, 8150041, 8186960, 11335962, 11361201, 11362959, 11365521, 11368083, 11372530, 11373828, 11376245, 11462173, 11484199, 11488328, 11491421, 11491990, 11493919, 14899359, 14923888, 43117983, 46507295, 47365229, 48035158, 48415808, 49666065, 49666423, 49830418, 50064182, 50111396, 50139266, 50300054, 51092025, 56320467, 85787400, 89736084, 92309297, 92309332, 92717149, 93166442, 93625433, 99301875, 99309408, 103724173, 104153271, 104170201, 104178839, 104321200, 117481059, 117776384, 121362382
Target and Pathway
Target(s) P2Y purinoceptor 12 Target Info Antagonist [527109]
KEGG Pathway Platelet activation
Reactome P2Y receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Signal amplification
GPCR ligand binding
GPCR downstream signaling
References
Ref 542158(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7150).
Ref 548841Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800029432)
Ref 527109P2Y12, a new platelet ADP receptor, target of clopidogrel. Semin Vasc Med. 2003 May;3(2):113-22.

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