Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0MH1X
|
||||
| Former ID |
DIB018931
|
||||
| Drug Name |
AZD1332
|
||||
| Synonyms |
AZD 1332; AZD-1332
|
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C17H19ClFN7O
|
||||
| InChI |
InChI=1S/C17H19ClFN7O/c1-9(2)27-15-6-14(25-26-15)23-16-12(18)8-21-17(24-16)22-10(3)13-5-4-11(19)7-20-13/h4-10H,1-3H3,(H3,21,22,23,24,25,26)
|
||||
| InChIKey |
LBVKEEFIPBQIMD-UHFFFAOYSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Trk receptor | Target Info | Inhibitor | [2] | |
| BDNF/NT-3 growth factors receptor | Target Info | Inhibitor | [3] | ||
| KEGG Pathway | MAPK signaling pathway | ||||
| Neurotrophin signaling pathway | |||||
| Alcoholism | |||||
| Pathway Interaction Database | SHP2 signaling | ||||
| Posttranslational regulation of adherens junction stability and dissassembly | |||||
| Neurotrophic factor-mediated Trk receptor signaling | |||||
| Reactome | ARMS-mediated activation | ||||
| NGF-independant TRKA activation | |||||
| PI3K/AKT activationR-HSA-187024:NGF-independant TRKA activation | |||||
| WikiPathways | MAPK Signaling Pathway | ||||
| BDNF signaling pathway | |||||
| Integrated Pancreatic Cancer Pathway | |||||
| NGF signalling via TRKA from the plasma membraneWP706:SIDS Susceptibility Pathways | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7700). | ||||
| REF 2 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1817). | ||||
| REF 3 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1818). | ||||
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