Drug Information
Drug General Information | |||||
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Drug ID |
D0MH1X
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Former ID |
DIB018931
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Drug Name |
AZD1332
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Synonyms |
AZD 1332; AZD-1332
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Investigative | [1] | ||
Structure |
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Download2D MOL |
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Formula |
C17H19ClFN7O
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InChI |
InChI=1S/C17H19ClFN7O/c1-9(2)27-15-6-14(25-26-15)23-16-12(18)8-21-17(24-16)22-10(3)13-5-4-11(19)7-20-13/h4-10H,1-3H3,(H3,21,22,23,24,25,26)
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InChIKey |
LBVKEEFIPBQIMD-UHFFFAOYSA-N
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PubChem Compound ID | |||||
PubChem Substance ID | |||||
Target and Pathway | |||||
Target(s) | Trk receptor | Target Info | Inhibitor | [2] | |
BDNF/NT-3 growth factors receptor | Target Info | Inhibitor | [3] | ||
KEGG Pathway | MAPK signaling pathway | ||||
Neurotrophin signaling pathway | |||||
Alcoholism | |||||
Pathway Interaction Database | SHP2 signaling | ||||
Posttranslational regulation of adherens junction stability and dissassembly | |||||
Neurotrophic factor-mediated Trk receptor signaling | |||||
Reactome | ARMS-mediated activation | ||||
NGF-independant TRKA activation | |||||
PI3K/AKT activationR-HSA-187024:NGF-independant TRKA activation | |||||
WikiPathways | MAPK Signaling Pathway | ||||
BDNF signaling pathway | |||||
Integrated Pancreatic Cancer Pathway | |||||
NGF signalling via TRKA from the plasma membraneWP706:SIDS Susceptibility Pathways | |||||
References | |||||
REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7700). | ||||
REF 2 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1817). | ||||
REF 3 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1818). | ||||
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