Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0M7ZZ
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| Former ID |
DNC010671
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| Drug Name |
Erysubin E
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
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Download2D MOL |
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| Formula |
C25H26O5
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| Canonical SMILES |
CC(=CCC1=C(C=C2C(=C1)C3C(CO2)(C4=C(O3)C5=C(C=C4)OC(C=C5<br />)(C)C)O)O)C
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| InChI |
1S/C25H26O5/c1-14(2)5-6-15-11-17-21(12-19(15)26)28-13-25(27)18-7-8-20-16(22(18)29-23(17)25)9-10-24(3,4)30-20/h5,7-12,23,26-27H,6,13H2,1-4H3/t23-,25+/m0/s1
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| InChIKey |
CMHGFGMNRHHGSN-UKILVPOCSA-N
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Neuraminidase | Target Info | Inhibitor | [2] | |
| mRNA of Protein tyrosine phosphatase-1B | Target Info | Inhibitor | [1] | ||
| KEGG Pathway | Other glycan degradationhsa04520:Adherens junction | ||||
| Insulin signaling pathway | |||||
| NetPath Pathway | FSH Signaling Pathway | ||||
| PANTHER Pathway | Cadherin signaling pathway | ||||
| Pathway Interaction Database | Insulin Pathway | ||||
| Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) | |||||
| Signaling events mediated by PTP1B | |||||
| Calcineurin-regulated NFAT-dependent transcription in lymphocytes | |||||
| Signaling events mediated by TCPTP | |||||
| IGF1 pathway | |||||
| EGF receptor (ErbB1) signaling pathway | |||||
| Posttranslational regulation of adherens junction stability and dissassembly | |||||
| PDGFR-beta signaling pathway | |||||
| N-cadherin signaling events | |||||
| Reactome | Integrin alphaIIb beta3 signaling | ||||
| Regulation of IFNG signaling | |||||
| Regulation of IFNA signaling | |||||
| Growth hormone receptor signaling | |||||
| WikiPathways | Insulin Signaling | ||||
| Growth hormone receptor signaling | |||||
| Leptin signaling pathway | |||||
| Interferon gamma signaling | |||||
| Interferon alpha/beta signaling | |||||
| Integrin alphaIIb beta3 signaling | |||||
| References | |||||
| REF 1 | Bioorg Med Chem Lett. 2009 Dec 1;19(23):6745-9. Epub 2009 Oct 1.Cytotoxic and PTP1B inhibitory activities from Erythrina abyssinica. | ||||
| REF 2 | Bioorg Med Chem. 2010 May 1;18(9):3335-44. Epub 2010 Mar 9.Prenylated pterocarpans as bacterial neuraminidase inhibitors. | ||||
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