Drug Information

Drug General Information
Drug ID
D0M7DE
Former ID
DNC010663
Drug Name
N-(1-benzofuran-3-ylmethyl)sulfamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530089]
Structure
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2D MOL

3D MOL
Formula
C9H10N2O3S
Canonical SMILES
C1=CC=C2C(=C1)C(=CO2)CNS(=O)(=O)N
InChI
1S/C9H10N2O3S/c10-15(12,13)11-5-7-6-14-9-4-2-1-3-8(7)9/h1-4,6,11H,5H2,(H2,10,12,13)
InChIKey
XOBOZYKTCAJRGO-UHFFFAOYSA-N
PubChem Compound ID
11521450
Target and Pathway
Target(s) Carbonic anhydrase II Target Info Inhibitor [530089]
KEGG Pathway Nitrogen metabolism
Proximal tubule bicarbonate reclamation
Collecting duct acid secretion
Gastric acid secretion
Pancreatic secretion
Bile secretion
NetPath Pathway IL4 Signaling Pathway
EGFR1 Signaling Pathway
Reactome Erythrocytes take up carbon dioxide and release oxygen
Erythrocytes take up oxygen and release carbon dioxide
Reversible hydration of carbon dioxide
WikiPathways Reversible Hydration of Carbon Dioxide
Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes
References
Ref 530089J Med Chem. 2009 Dec 10;52(23):7528-36.Novel, broad-spectrum anticonvulsants containing a sulfamide group: advancement of N-((benzo[b]thien-3-yl)methyl)sulfamide (JNJ-26990990) into human clinical studies.
Ref 530089J Med Chem. 2009 Dec 10;52(23):7528-36.Novel, broad-spectrum anticonvulsants containing a sulfamide group: advancement of N-((benzo[b]thien-3-yl)methyl)sulfamide (JNJ-26990990) into human clinical studies.

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