Drug Information

Drug General Information
Drug ID
D0M5PB
Former ID
DIB019881
Drug Name
FTI 276
Synonyms
FTI-276; FTI276
Drug Type
Small molecular drug
Indication Discovery agent Investigative [526501]
Structure
Download
2D MOL
Formula
C21H27N3O3S2
InChI
InChI=1S/C21H27N3O3S2/c1-29-10-9-19(21(26)27)24-20(25)17-8-7-16(23-12-15(22)13-28)11-18(17)14-5-3-2-4-6-14/h2-8,11,15,19,23,28H,9-10,12-13,22H2,1H3,(H,24,25)(H,26,27)/t15-,19+/m1/s1
InChIKey
ZIXDDEATQSBHHL-BEFAXECRSA-N
PubChem Compound ID
395754
PubChem Substance ID
14832415, 23932895, 29217554, 49992383, 74707342, 103241910, 103962023, 104625299, 129909261, 177748875, 178103145, 179117177, 228807810
Target and Pathway
Target(s) Protein farnesyltransferase beta subunit Target Info Inhibitor [533648]
KEGG Pathway Terpenoid backbone biosynthesis
Biosynthesis of antibiotics
NetPath Pathway TSH Signaling Pathway
Reactome Inactivation, recovery and regulation of the phototransduction cascade
WikiPathways Visual phototransduction
References
Ref 526501Targeting RAS signalling pathways in cancer therapy. Nat Rev Cancer. 2003 Jan;3(1):11-22.
Ref 533648Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic Ras signaling by inducing cytoplasmic accumulation of inactive Ras-Raf complexes. J Biol Chem. 1995 Nov 10;270(45):26802-6.

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