Drug Information

Drug General Information
Drug ID
D0M5HY
Former ID
DIB019100
Drug Name
CDPPB
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538900]
Structure
Download
2D MOL
Formula
C23H16N4O
InChI
InChI=1S/C23H16N4O/c24-16-17-8-7-11-19(14-17)23(28)25-22-15-21(18-9-3-1-4-10-18)26-27(22)20-12-5-2-6-13-20/h1-15H,(H,25,28)
InChIKey
BKUIZWILNWHFHD-UHFFFAOYSA-N
PubChem Compound ID
11245456
PubChem Substance ID
16330111, 23423727, 26759128, 42325007, 53788196, 53800679, 56310618, 57376329, 77736367, 93580910, 103458993, 104043351, 123044929, 123392804, 125654101, 126582271, 126634558, 126739012, 134348493, 135343993, 135650062, 135698868, 137007772, 137249726, 139466067, 162220792, 162913781, 163687721, 163781184, 201507959, 204366790, 208264896, 208265549, 227996902, 241376330, 244698141, 252157115
Target and Pathway
Target(s) Metabotropic glutamate receptor 5 Target Info Modulator (allosteric modulator) [527282]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Huntington's disease
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Endogenous cannabinoid signaling
Reactome G alpha (q) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways Hypothetical Network for Drug Addiction
GPCRs, Class C Metabotropic glutamate, pheromone
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 538900(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1422).
Ref 527282Discovery of positive allosteric modulators for the metabotropic glutamate receptor subtype 5 from a series of N-(1,3-diphenyl-1H- pyrazol-5-yl)benzamides that potentiate receptor function in vivo. JMed Chem. 2004 Nov 18;47(24):5825-8.

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