Drug Information
Drug General Information | |||||
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Drug ID |
D0M4PH
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Former ID |
DIB009174
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Drug Name |
LOXO-101
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Indication | Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] | Phase 1 | [1] | ||
Company |
Array biopharma; loxo oncology
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Structure |
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Download2D MOL |
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Target and Pathway | |||||
Target(s) | BDNF/NT-3 growth factors receptor | Target Info | Inhibitor | [2] | |
Trk receptor | Target Info | Inhibitor | [3] | ||
Neurotrophic tyrosine kinase receptor 1 | Target Info | Inhibitor | [4] | ||
KEGG Pathway | MAPK signaling pathway | ||||
Neurotrophin signaling pathway | |||||
Alcoholismhsa04010:MAPK signaling pathway | |||||
Endocytosis | |||||
Apoptosis | |||||
Inflammatory mediator regulation of TRP channels | |||||
Pathways in cancer | |||||
Transcriptional misregulation in cancer | |||||
Thyroid cancer | |||||
Central carbon metabolism in cancer | |||||
NetPath Pathway | IL2 Signaling Pathway | ||||
Pathway Interaction Database | SHP2 signaling | ||||
Posttranslational regulation of adherens junction stability and dissassembly | |||||
Neurotrophic factor-mediated Trk receptor signalingtrkrpathway:Neurotrophic factor-mediated Trk receptor signaling | |||||
Reactome | NGF-independant TRKA activationR-HSA-170984:ARMS-mediated activation | ||||
NGF-independant TRKA activation | |||||
PI3K/AKT activationR-HSA-170968:Frs2-mediated activation | |||||
ARMS-mediated activation | |||||
PI3K/AKT activation | |||||
WikiPathways | SIDS Susceptibility Pathways | ||||
BDNF signaling pathwayWP382:MAPK Signaling Pathway | |||||
BDNF signaling pathway | |||||
Integrated Pancreatic Cancer Pathway | |||||
NGF signalling via TRKA from the plasma membraneWP382:MAPK Signaling Pathway | |||||
NGF signalling via TRKA from the plasma membrane | |||||
References | |||||
REF 1 | ClinicalTrials.gov (NCT02122913) Oral TRK Inhibitor LOXO-101 for Treatment of Advanced Adult Solid Tumors. U.S. National Institutes of Health. | ||||
REF 2 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1818). | ||||
REF 3 | ALK inhibitors in non-small cell lung cancer: crizotinib and beyond. Clin Adv Hematol Oncol. 2014 Jul;12(7):429-39. | ||||
REF 4 | Clinical pipeline report, company report or official report of Loxo Oncology. | ||||
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