Drug General Information
Drug ID	D0M3OR
Former ID	DNCL002531
Drug Name	KW-2450
Indication	Breast cancer [ICD9: 174, 175; ICD10:C50]		Discontinued in Phase 1/2	[548938]
Company	Kyowa Hakko Kirin Pharma
Structure		Download 2D MOL
Target and Pathway
Target(s)	Insulin-like growth factor I receptor	Target Info	Modulator	[1572591]
	Insulin receptor	Target Info	Modulator	[1572591]
KEGG Pathway	Ras signaling pathway
	Rap1 signaling pathway
	HIF-1 signaling pathway
	FoxO signaling pathway
	Oocyte meiosis
	Endocytosis
	PI3K-Akt signaling pathway
	AMPK signaling pathway
	Focal adhesion
	Adherens junction
	Signaling pathways regulating pluripotency of stem cells
	Long-term depression
	Ovarian steroidogenesis
	Progesterone-mediated oocyte maturation
	Pathways in cancer
	Transcriptional misregulation in cancer
	Proteoglycans in cancer
	Glioma
	Prostate cancer
	Melanomahsa04014:Ras signaling pathway
	cGMP-PKG signaling pathway
	Insulin signaling pathway
	Type II diabetes mellitus
	Non-alcoholic fatty liver disease (NAFLD)
	Aldosterone-regulated sodium reabsorption
NetPath Pathway	TGF_beta_Receptor Signaling Pathway
PANTHER Pathway	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
	Insulin/IGF pathway-protein kinase B signaling cascadeP00032:Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
	Insulin/IGF pathway-protein kinase B signaling cascade
	PI3 kinase pathway
Pathway Interaction Database	Plasma membrane estrogen receptor signaling
	SHP2 signaling
	IGF1 pathway
	Posttranslational regulation of adherens junction stability and dissassembly
	Integrins in angiogenesis
	Stabilization and expansion of the E-cadherin adherens junctioninsulin_pathway:Insulin Pathway
	Signaling events mediated by PTP1B
	Signaling events mediated by TCPTP
	Insulin-mediated glucose transport
PathWhiz Pathway	Insulin Signalling
	Leucine Stimulation on Insulin Signaling
Reactome	IRS-related events triggered by IGF1R
	SHC-related events triggered by IGF1RR-HSA-74713:IRS activation
	Signal attenuation
	Insulin receptor signalling cascade
	Insulin receptor recycling
WikiPathways	Senescence and Autophagy in Cancer
	Insulin Signaling
	Endochondral Ossification
	Focal Adhesion
	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
	Apoptosis
	Signaling Pathways in Glioblastoma
	TSH signaling pathway
	MicroRNAs in cardiomyocyte hypertrophyWP710:DNA Damage Response (only ATM dependent)
	Nanoparticle triggered autophagic cell death
	AGE/RAGE pathway
	Signaling by Insulin receptor
	Folate Metabolism
	Type II diabetes mellitus
	Vitamin B12 Metabolism
	Selenium Micronutrient Network
	AMPK Signaling
References
Ref 548938	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800030562)
Ref 1572591	Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.

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