Drug General Information
Drug ID	D0M2XE
Former ID	DAP001093
Drug Name	Insulin-glulisine
Indication	Diabetes [ICD9: 253.5, 588.1; ICD10:E23.2, N25.1]		Approved	[527466]
Therapeutic Class	Hypoglycemic Agents
Structure		Download 2D MOL
Formula	C258H384N64O78S6
CAS Number	CAS 207748-29-6
PubChem Compound ID	72941761
Target and Pathway
Target(s)	Insulin receptor	Target Info	Binder	[537423]
KEGG Pathway	Ras signaling pathway
	Rap1 signaling pathway
	cGMP-PKG signaling pathway
	HIF-1 signaling pathway
	FoxO signaling pathway
	PI3K-Akt signaling pathway
	AMPK signaling pathway
	Adherens junction
	Insulin signaling pathway
	Ovarian steroidogenesis
	Type II diabetes mellitus
	Non-alcoholic fatty liver disease (NAFLD)
	Aldosterone-regulated sodium reabsorption
NetPath Pathway	TGF_beta_Receptor Signaling Pathway
PANTHER Pathway	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
	Insulin/IGF pathway-protein kinase B signaling cascade
	PI3 kinase pathway
Pathway Interaction Database	Insulin Pathway
	Signaling events mediated by PTP1B
	Signaling events mediated by TCPTP
	Insulin-mediated glucose transport
PathWhiz Pathway	Insulin Signalling
	Leucine Stimulation on Insulin Signaling
Reactome	IRS activation
	Signal attenuation
	Insulin receptor signalling cascade
	Insulin receptor recycling
WikiPathways	DNA Damage Response (only ATM dependent)
	Insulin Signaling
	Nanoparticle triggered autophagic cell death
	AGE/RAGE pathway
	Signaling by Insulin receptor
	Folate Metabolism
	Type II diabetes mellitus
	Vitamin B12 Metabolism
	Selenium Micronutrient Network
	AMPK Signaling
References
Ref 527466	2004 approvals: the demise of the blockbuster. Nat Rev Drug Discov. 2005 Feb;4(2):93-4.
Ref 537423	Insulin glulisine: a review of its use in the management of diabetes mellitus. Drugs. 2009;69(8):1035-57. doi: 10.2165/00003495-200969080-00006.

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