Drug General Information |
Drug ID |
D0M2AN
|
Former ID |
DIB000670
|
Drug Name |
AD-412
|
Synonyms |
JAK3 inhibitor (autoimmune disease/transplant rejection), INSERM
|
Indication |
Autoimmune diabetes [ICD10:E08-E13]
|
Investigative |
[1]
|
Company |
INSERM
|
Structure |
|
Download
2D MOL
3D MOL
|
Canonical SMILES |
n1(cc(c2c1cccc2)CCC(=O)Nc1ccncc1)Cc1ccc(Cl)cc1
|
Target and Pathway |
Target(s) |
Tyrosine-protein kinase JAK3 |
Target Info |
Inhibitor |
[1]
|
KEGG Pathway
|
Chemokine signaling pathway
|
PI3K-Akt signaling pathway
|
Signaling pathways regulating pluripotency of stem cells
|
Jak-STAT signaling pathway
|
Measles
|
HTLV-I infection
|
Epstein-Barr virus infection
|
Viral carcinogenesis
|
Primary immunodeficiency
|
PANTHER Pathway
|
Interleukin signaling pathway
|
JAK/STAT signaling pathway
|
PDGF signaling pathway
|
Pathway Interaction Database
|
IL4-mediated signaling events
|
CD40/CD40L signaling
|
Signaling events mediated by TCPTP
|
SHP2 signaling
|
IL2-mediated signaling events
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IL2 signaling events mediated by PI3K
|
IL2 signaling events mediated by STAT5
|
Reactome
|
GPVI-mediated activation cascade
|
Interleukin-7 signaling
|
G beta:gamma signalling through PI3Kgamma
|
Interleukin-2 signaling
|
RAF/MAP kinase cascade
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Interleukin receptor SHC signaling
|
WikiPathways
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IL-2 Signaling Pathway
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IL-4 Signaling Pathway
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Interleukin-2 signaling
|
Interleukin-7 signaling
|
Oncostatin M Signaling Pathway
|
IL-9 Signaling Pathway
|
IL-7 Signaling Pathway
|
Interleukin-3, 5 and GM-CSF signaling
|
References |
REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2049). |