Drug Information

Drug General Information
Drug ID
D0M1IO
Former ID
DAP000710
Drug Name
Bacitracin
Synonyms
Altracin; Baciguent; Baciquent; Citracin; Fortracin; Bacitracin A; Bacitracin A1; Bacitracin A2a; Neosporin (TN); Solu-Tracin 50; Partyl-, (10.4)-lactam; L-Asparagine, N-[[(4R)-2-[(1S,2S)-1-amino-2-methylbutyl]-4,5-dihydro-4-thiazolyl]carbonyl]-L-leucyl-D-.alpha.-glutamyl-L-isoleucyl-L-lysyl-D-ornithyl-L-isoleucyl-D-phenylalanyl-L-histidyl-D-.alpha.-as; 11702_FLUKA; 11702_SIGMA
Drug Type
Small molecular drug
Indication Skin infections [ICD9: 680-709; ICD10:L00-L99] Approved [536854], [551871]
Therapeutic Class
Antibiotics
Structure
Download
2D MOL

3D MOL
Formula
C66H103N17O16S
Canonical SMILES
CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NCCCCC(C(=<br />O)NC(C(=O)N1)CCCN)NC(=O)C(C(C)CC)NC(=O)C(CCC(=O)O)NC(=O<br/>)C(CC(C)C)NC(=O)C2CSC(=N2)C(C(C)CC)N)CC(=O)N)CC(=O)O)CC<br />3=CN=CN3)CC4=CC=CC=C4
InChI
1S/C66H103N17O16S/c1-9-35(6)52(69)66-81-48(32-100-66)63(97)76-43(26-34(4)5)59(93)74-42(22-23-50(85)86)58(92)83-53(36(7)10-2)64(98)75-40-20-15-16-25-71-55(89)46(29-49(68)84)78-62(96)47(30-51(87)88)79-61(95)45(28-39-31-70-33-72-39)77-60(94)44(27-38-18-13-12-14-19-38)80-65(99)54(37(8)11-3)82-57(91)41(21-17-24-67)73-56(40)90/h12-14,18-19,31,33-37,40-48,52-54H,9-11,15-17,20-30,32,67,69H2,1-8H3,(H2,68,84)(H,70,72)(H,71,89)(H,73,90)(H,74,93)(H,75,98)(H,76,97)(H,77,94)(H,78,96)(H,79,95)(H,80,99)(H,82,91)(H,83,92)(H,85,86)(H,87,88)/t35-,36-,37-,40-,41+,42+,43-,44+,45-,46-,47+,48-,52-,53-,54-/m0/s1
InChIKey
CLKOFPXJLQSYAH-ABRJDSQDSA-N
CAS Number
CAS 1405-87-4
PubChem Compound ID
10909430
PubChem Substance ID
15958136, 17396476, 23151820, 26514780, 46504727, 79565370, 103770541, 162251230, 175266973, 175269018, 224054832, 252819707
ChEBI ID
ChEBI:28669
SuperDrug ATC ID
D06AX05; J01XX10; R02AB04
SuperDrug CAS ID
cas=001405874
Target and Pathway
Target(s) Insulin-degrading Enzyme Target Info Inhibitor [536012]
KEGG Pathway Alzheimer's disease
WikiPathways Alzheimers Disease
References
Ref 536854Has nature already identified all useful antibacterial targets? Curr Opin Microbiol. 2008 Oct;11(5):387-92. Epub 2008 Oct 6.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 536012Brain insulin impairs amyloid-beta(1-40) clearance from the brain. J Neurosci. 2004 Oct 27;24(43):9632-7.

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