Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0M0ZX
|
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| Former ID |
DNC013004
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| Drug Name |
6-ethyl-3-(2-ethylbutoxycarbonyl)-4-quinolone
|
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C18H23NO3
|
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| Canonical SMILES |
CCC1=CC2=C(C=C1)NC=C(C2=O)C(=O)OCC(CC)CC
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| InChI |
1S/C18H23NO3/c1-4-12(5-2)11-22-18(21)15-10-19-16-8-7-13(6-3)9-14(16)17(15)20/h7-10,12H,4-6,11H2,1-3H3,(H,19,20)
|
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| InChIKey |
ANYBYQLGVQJDTI-UHFFFAOYSA-N
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Gamma-aminobutyric acid receptor | Target Info | Inhibitor | [1] | |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Target Info | Inhibitor | [1] | ||
| Gamma-aminobutyric acid receptor subunit beta-2 | Target Info | Inhibitor | [1] | ||
| Gamma-aminobutyric acid receptor subunit alpha-1 | Target Info | Inhibitor | [1] | ||
| KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
| Retrograde endocannabinoid signaling | |||||
| GABAergic synapse | |||||
| Morphine addiction | |||||
| Nicotine addictionhsa04080:Neuroactive ligand-receptor interaction | |||||
| Serotonergic synapse | |||||
| Nicotine addiction | |||||
| Reactome | Ligand-gated ion channel transport | ||||
| GABA A receptor activationR-HSA-975298:Ligand-gated ion channel transport | |||||
| GABA A receptor activation | |||||
| WikiPathways | Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | ||||
| Iron uptake and transportWP2754:Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | |||||
| Iron uptake and transportWP706:SIDS Susceptibility Pathways | |||||
| Iron uptake and transport | |||||
| References | |||||
| REF 1 | J Med Chem. 2006 Apr 20;49(8):2526-33.4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore modeling. | ||||
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