Drug Information
Drug General Information | |||||
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Drug ID |
D0M0RN
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Former ID |
DIB001837
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Drug Name |
SCH-42495
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Synonyms |
N-[2(S)-(Acetylsulfanylmethyl)-3-(2-methylphenyl)propionyl]-L-methionine ethyl ester
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Drug Type |
Small molecular drug
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Indication | Hypotension [ICD9: 458, 796.3; ICD10:I95] | Discontinued in Phase 2 | [545085] | ||
Structure |
Download2D MOL |
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Formula |
C20H29NO4S2
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Canonical SMILES |
CCOC(=O)C(CCSC)NC(=O)C(CC1=CC=CC=C1C)CSC(=O)C
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InChI |
1S/C20H29NO4S2/c1-5-25-20(24)18(10-11-26-4)21-19(23)17(13-27-15(3)22)12-16-9-7-6-8-14(16)2/h6-9,17-18H,5,10-13H2,1-4H3,(H,21,23)/t17-,18+/m1/s1
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InChIKey |
ZVQXPUMRSJGLSF-MSOLQXFVSA-N
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PubChem Compound ID | |||||
PubChem Substance ID | |||||
Target and Pathway | |||||
Target(s) | Neutral endopeptidase | Target Info | Inhibitor | [531869], [534015] | |
NetPath Pathway | EGFR1 Signaling Pathway | ||||
TGF_beta_Receptor Signaling Pathway | |||||
References | |||||
Ref 531869 | The dual endothelin converting enzyme/neutral endopeptidase inhibitor SLV-306 (daglutril), inhibits systemic conversion of big endothelin-1 in humans. Life Sci. 2012 Oct 15;91(13-14):743-8. | ||||
Ref 534015 | Endopeptidase 24.11 inhibition by SCH 42495 in essential hypertension. Hypertension. 1993 Jul;22(1):119-26. |
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