| Drug General Information |
| Drug ID |
D0LP5G
|
| Former ID |
DNC012550
|
| Drug Name |
2-Phenyl-1H-imidazo[4,5-c]quinolin-4-ylamine
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C16H12N4
|
| Canonical SMILES |
C1=CC=C(C=C1)C2=NC3=C(N2)C(=NC4=CC=CC=C43)N
|
| InChI |
1S/C16H12N4/c17-15-14-13(11-8-4-5-9-12(11)18-15)19-16(20-14)10-6-2-1-3-7-10/h1-9H,(H2,17,18)(H,19,20)
|
| InChIKey |
IBRIUJBAFMFSDF-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Adenosine A2a receptor |
Target Info |
Inhibitor |
[1]
|
|---|
| Adenosine A1 receptor |
Target Info |
Inhibitor |
[1]
|
| Adenosine A2b receptor |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
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Rap1 signaling pathway
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|
Calcium signaling pathway
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cAMP signaling pathway
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Neuroactive ligand-receptor interaction
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Vascular smooth muscle contraction
|
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Parkinson's disease
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Alcoholismhsa04022:cGMP-PKG signaling pathway
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Sphingolipid signaling pathway
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Morphine addictionhsa04015:Rap1 signaling pathway
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Alcoholism
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NetPath Pathway
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TCR Signaling Pathway
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RANKL Signaling PathwayNetPath_7:TGF_beta_Receptor Signaling Pathway
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PANTHER Pathway
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Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
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Pathway Interaction Database
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HIF-2-alpha transcription factor networkcmyb_pathway:C-MYB transcription factor network
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PathWhiz Pathway
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Intracellular Signalling Through Adenosine Receptor A2a and AdenosinePW000446:Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
|
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Reactome
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NGF-independant TRKA activation
|
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Adenosine P1 receptors
|
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G alpha (s) signalling events
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Surfactant metabolismR-HSA-417973:Adenosine P1 receptors
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G alpha (i) signalling eventsR-HSA-417973:Adenosine P1 receptors
|
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Surfactant metabolism
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|
WikiPathways
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Nucleotide GPCRs
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Monoamine Transport
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GPCRs, Class A Rhodopsin-like
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NGF signalling via TRKA from the plasma membrane
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GPCR ligand binding
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GPCR downstream signaling
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GPCRs, OtherWP80:Nucleotide GPCRs
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GPCR downstream signalingWP80:Nucleotide GPCRs
|
| References |
| REF 1 | J Med Chem. 1991 Mar;34(3):1202-6.1H-imidazo[4,5-c]quinolin-4-amines: novel non-xanthine adenosine antagonists. |
|---|
