| Drug General Information |
| Drug ID |
D0LD0X
|
| Former ID |
DNC004200
|
| Drug Name |
1-Propyl-3,7-dihydro-purine-2,6-dione
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C8H10N4O2
|
| Canonical SMILES |
CCCN1C(=O)C2=C(NC1=O)N=CN2
|
| InChI |
1S/C8H10N4O2/c1-2-3-12-7(13)5-6(10-4-9-5)11-8(12)14/h4H,2-3H2,1H3,(H,9,10)(H,11,14)
|
| InChIKey |
IWBONKMODGBEOX-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Adenosine A3 receptor |
Target Info |
Inhibitor |
[1]
|
|---|
| Adenosine A2b receptor |
Target Info |
Inhibitor |
[1]
|
| Adenosine A1 receptor |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
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Rap1 signaling pathway
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Calcium signaling pathway
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Neuroactive ligand-receptor interaction
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Vascular smooth muscle contraction
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Alcoholismhsa04022:cGMP-PKG signaling pathway
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cAMP signaling pathway
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Sphingolipid signaling pathway
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Morphine addiction
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NetPath Pathway
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TGF_beta_Receptor Signaling Pathway
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TCR Signaling PathwayNetPath_11:TCR Signaling Pathway
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RANKL Signaling Pathway
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PANTHER Pathway
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Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
|
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Pathway Interaction Database
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C-MYB transcription factor network
|
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PathWhiz Pathway
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Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
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Reactome
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Adenosine P1 receptors
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G alpha (i) signalling eventsR-HSA-417973:Adenosine P1 receptors
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G alpha (s) signalling events
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Surfactant metabolismR-HSA-417973:Adenosine P1 receptors
|
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G alpha (i) signalling events
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WikiPathways
|
Nucleotide GPCRs
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GPCRs, Class A Rhodopsin-like
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GPCRs, OtherWP80:Nucleotide GPCRs
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GPCR ligand binding
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GPCR downstream signalingWP80:Nucleotide GPCRs
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GPCR downstream signaling
|
| References |
| REF 1 | J Med Chem. 2002 May 23;45(11):2131-8.Structure-activity relationships at human and rat A2B adenosine receptors of xanthine derivatives substituted at the 1-, 3-, 7-, and 8-positions. |
|---|
