Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0LB0N
|
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| Former ID |
DNC009962
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| Drug Name |
5-(biphenyl-4-yl)-3-oxopentanoic acid
|
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C17H16O3
|
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| Canonical SMILES |
C1=CC=C(C=C1)C2=CC=C(C=C2)CCC(=O)CC(=O)O
|
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| InChI |
1S/C17H16O3/c18-16(12-17(19)20)11-8-13-6-9-15(10-7-13)14-4-2-1-3-5-14/h1-7,9-10H,8,11-12H2,(H,19,20)
|
||||
| InChIKey |
HDXADAWBGFXTBW-UHFFFAOYSA-N
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | MMP-12 | Target Info | Inhibitor | [1] | |
| NetPath Pathway | IL1 Signaling Pathway | ||||
| IL5 Signaling Pathway | |||||
| Pathway Interaction Database | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling | ||||
| Reactome | Collagen degradation | ||||
| Degradation of the extracellular matrix | |||||
| WikiPathways | TGF beta Signaling Pathway | ||||
| Degradation of collagen | |||||
| Matrix Metalloproteinases | |||||
| References | |||||
| REF 1 | Bioorg Med Chem Lett. 2009 Oct 1;19(19):5760-3. Epub 2009 Aug 6.The identification of beta-hydroxy carboxylic acids as selective MMP-12 inhibitors. | ||||
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