Drug Information

Drug General Information
Drug ID
D0LB0N
Former ID
DNC009962
Drug Name
5-(biphenyl-4-yl)-3-oxopentanoic acid
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530333]
Structure
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2D MOL

3D MOL
Formula
C17H16O3
Canonical SMILES
C1=CC=C(C=C1)C2=CC=C(C=C2)CCC(=O)CC(=O)O
InChI
1S/C17H16O3/c18-16(12-17(19)20)11-8-13-6-9-15(10-7-13)14-4-2-1-3-5-14/h1-7,9-10H,8,11-12H2,(H,19,20)
InChIKey
HDXADAWBGFXTBW-UHFFFAOYSA-N
PubChem Compound ID
45483008
Target and Pathway
Target(s) MMP-12 Target Info Inhibitor [530333]
NetPath Pathway IL1 Signaling Pathway
IL5 Signaling Pathway
Pathway Interaction Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Reactome Collagen degradation
Degradation of the extracellular matrix
WikiPathways TGF beta Signaling Pathway
Degradation of collagen
Matrix Metalloproteinases
References
Ref 530333Bioorg Med Chem Lett. 2009 Oct 1;19(19):5760-3. Epub 2009 Aug 6.The identification of beta-hydroxy carboxylic acids as selective MMP-12 inhibitors.
Ref 530333Bioorg Med Chem Lett. 2009 Oct 1;19(19):5760-3. Epub 2009 Aug 6.The identification of beta-hydroxy carboxylic acids as selective MMP-12 inhibitors.

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