Drug Information

Drug General Information
Drug ID
D0L9VP
Former ID
DNC009400
Drug Name
GNF-PF-5434
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529350]
Structure
Download
2D MOL

3D MOL
Formula
C28H37N3O5S
Canonical SMILES
CC(C)CC(C(=O)NC(CCC1=CC=CC=C1)C=CS(=O)(=O)C2=CC=CC=C2)N<br />C(=O)N3CCOCC3
InChI
1S/C28H37N3O5S/c1-22(2)21-26(30-28(33)31-16-18-36-19-17-31)27(32)29-24(14-13-23-9-5-3-6-10-23)15-20-37(34,35)25-11-7-4-8-12-25/h3-12,15,20,22,24,26H,13-14,16-19,21H2,1-2H3,(H,29,32)(H,30,33)/b20-15+/t24-,26-/m0/s1
InChIKey
YUMYYTORLYHUFW-MSKIIMLESA-N
PubChem Compound ID
5287864
Target and Pathway
Target(s) Cathepsin K Target Info Inhibitor [529350]
Cathepsin B Target Info Inhibitor [529350]
Cathepsin S Target Info Inhibitor [529350]
Dipeptidyl-peptidase I Target Info Inhibitor [529350]
KEGG Pathway Lysosome
Osteoclast differentiation
Toll-like receptor signaling pathway
Rheumatoid arthritishsa04142:Lysosome
Antigen processing and presentationhsa04142:Lysosome
Phagosome
Antigen processing and presentation
Tuberculosishsa04142:Lysosome
NetPath Pathway TGF_beta_Receptor Signaling Pathway
RANKL Signaling Pathway
IL2 Signaling PathwayNetPath_11:TCR Signaling Pathway
IL2 Signaling PathwayNetPath_22:Leptin Signaling Pathway
IL2 Signaling PathwayNetPath_14:IL2 Signaling Pathway
IL4 Signaling Pathway
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Trafficking and processing of endosomal TLR
MHC class II antigen presentationR-HSA-1442490:Collagen degradation
Assembly of collagen fibrils and other multimeric structures
MHC class II antigen presentationR-HSA-1236977:Endosomal/Vacuolar pathway
MHC class II antigen presentationR-HSA-204005:COPII (Coat Protein 2) Mediated Vesicle Transport
MHC class II antigen presentation
Cargo concentration in the ER
WikiPathways RANKL/RANK Signaling Pathway
Osteoclast SignalingWP2796:Class I MHC mediated antigen processing & presentation
Trafficking and processing of endosomal TLRWP2005:miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in leukocytes - TarBase
miR-targeted genes in epithelium - TarBase
References
Ref 529350Bioorg Med Chem. 2009 Feb 1;17(3):1064-70. Epub 2008 Feb 7.Substrate optimization for monitoring cathepsin C activity in live cells.
Ref 529350Bioorg Med Chem. 2009 Feb 1;17(3):1064-70. Epub 2008 Feb 7.Substrate optimization for monitoring cathepsin C activity in live cells.

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