Drug General Information
Drug ID
D0L9NX
Former ID
DCL000974
Drug Name
Satavaptan
Synonyms
Aquilda; SR-121463; SR-121463A; SR-121463B; SR-121463F; Benzamide, N-(1,1-dimethylethyl)-4-((cis-5'-ethoxy-4-(2-(4-morpholinyl)ethoxy)-2'-oxospiro(cyclohexane-1,3'-(3H)indol)-1'(2'H)-yl)sulfonyl)-3-methoxy-, phosphate (1:1)
Drug Type
Small molecular drug
Indication Acute and chronic heart failure [ICD9: 428; ICD10:I50] Phase 3 [537062], [539398]
Company
Sanofi-Aventis
Structure
Download
2D MOL

3D MOL

Formula
C37H49N3O12S
InChI
InChI=1S/C33H45N3O8S/c1-6-43-25-8-9-27-26(22-25)33(13-11-24(12-14-33)44-20-17-35-15-18-42-19-16-35)31(38)36(27)45(39,40)29-10-7-23(21-28(29)41-5)30(37)34-32(2,3)4/h7-10,21-22,24H,6,11-20H2,1-5H3,(H,34,37)/t24-,33+
InChIKey
QKXJWFOKVQWEDZ-VCCCEUOBSA-N
CAS Number
CAS 185913-78-4
PubChem Compound ID
PubChem Substance ID
SuperDrug ATC ID
A08AA03
SuperDrug CAS ID
cas=000090846
Target and Pathway
Target(s) Vasopressin V2 receptor Target Info Antagonist [537062]
KEGG Pathway Neuroactive ligand-receptor interaction
Vasopressin-regulated water reabsorption
Pathway Interaction Database Arf6 trafficking events
PathWhiz Pathway Vasopressin Regulation of Water Homeostasis
Reactome Vasopressin-like receptors
G alpha (s) signalling events
Vasopressin regulates renal water homeostasis via Aquaporins
WikiPathways GPCRs, Class A Rhodopsin-like
Regulation of Water Balance by Renal Aquaporins
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 537062Post-translational import of protein into the endoplasmic reticulum of a trypanosome: an in vitro system for discovery of anti-trypanosomal chemical entities. Biochem J. 2009 Apr 15;419(2):507-17.
Ref 539398(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2199).
Ref 537062Post-translational import of protein into the endoplasmic reticulum of a trypanosome: an in vitro system for discovery of anti-trypanosomal chemical entities. Biochem J. 2009 Apr 15;419(2):507-17.

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